Evidence map›Paper›PMID 26472474›Full record

ArticleCancer causes & control : CCC2016

Energy homeostasis genes and survival after breast cancer diagnosis: the Breast Cancer Health Disparities Study.

Andrew J Pellatt, Abbie Lundgreen, Roger K Wolff, Lisa Hines, Esther M John, Martha L Slattery

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Andrew J Pellatt
Abbie Lundgreen
Roger K Wolff
Lisa Hines
Esther M John
Martha L Slattery
University of Utah · USStanford University · USUniversity of Colorado Colorado Springs · US

Funding

CALIFORNIA'S PARTICIPATION IN THE NATIONAL CANCER PREVENTION AND CONTRO PROGRAMU58DP000807 · DP · PUBLIC HEALTH INSTITUTE · PI SNIPES, KURT P · 2007 to 2011
$22.5M
FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYR01CA078682 · NCI · UNIVERSITY OF UTAH · PI SLATTERY, MARTHA OR MARTY L · 1999 to 2003
$4.0M
Disparities in Breast Cancer: Development and Survival in Hispanic and NHW WomenR01CA140002 · NCI · UNIVERSITY OF UTAH · PI SLATTERY, MARTHA L · 2009 to 2013
$3.1M
THE 4 CORNERS BREAST AND ENDOMETRIAL CANCER STUDYR01CA078762 · NCI · UNIVERSITY OF NEW MEXICO · PI BAUMGARTNER, KATHY B · 1999 to 2003
$3.0M
FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDYR01CA078802 · NCI · UNIVERSITY OF ARIZONA · PI MARTINEZ, MARIA ELENA · 1999 to 2003
$2.2M
FOUR-CORNERS BREAST CANCER STUDYR01CA078552 · NCI · UNIVERSITY OF COLORADO DENVER · PI BYERS, TIM E · 1999 to 2003
$1.5M
VITAMIN D RECEPTOR GENE POLYMORPHISM AND BREAST CANCERR01CA077305 · NCI · NORTHERN CALIFORNIA CANCER CENTER · PI JOHN, ESTHER M · 1999 to 2001
$834k
BREAST CANCER RISK FACTORS IN HISPANIC WOMENR01CA063446 · NCI · NORTHERN CALIFORNIA CANCER CENTER · PI JOHN, ESTHER M · 1995 to 1998
–
NCCDPHP CDC HHS #1U58DP000807-01NCCDPHP CDC HHS U58 DP000807NCI NIH HHS CA078552NCI NIH HHS CA078682NCI NIH HHS CA078762NCI NIH HHS CA078802NCI NIH HHS CA14002NCI NIH HHS CA77305NCI NIH HHS HHSN261201000036CNCI NIH HHS R01 CA063446NCI NIH HHS R01 CA078552NCI NIH HHS R01 CA078682NCI NIH HHS R01 CA078762NCI NIH HHS R01 CA078802NCI NIH HHS R01 CA140002
6 · The paper itself

Abstract

purposeThe leptin-signaling pathway and other genes involved in energy homeostasis (EH) have been examined in relation to breast cancer risk as well as to obesity. We test the hypothesis that genetic variation in EH genes influences survival after diagnosis with breast cancer and that body mass index (BMI) will modify that risk.

methodsWe evaluated associations between 10 EH genes and survival among 1,186 non-Hispanic white and 1,155 Hispanic/Native American women diagnosed with breast cancer. Percent Native American (NA) ancestry was determined from 104 ancestry-informative markers. Adaptive rank truncation product (ARTP) was used to determine gene and pathway significance.

resultsThe overall EH pathway was marginally significant for all-cause mortality among women with low NA ancestry (P(ARTP) = 0.057). Within the pathway, ghrelin(GHRL) and leptin receptor (LEPR) were significantly associated with all-cause mortality (P(ARTP) = 0.035 and 0.007, respectively). The EH pathway was significantly associated with breast cancer-specific mortality among women with low NA ancestry (P(ARTP) = 0.038). Three genes cholecystokinin (CCK), GHRL, and LEPR were significantly associated with breast cancer-specific mortality among women with low NA ancestry (P(ARTP) = 0.046,0.015, and 0.046, respectively), while neuropeptide Y (NPY) was significantly associated with breast cancer-specific mortality among women with higher NA ancestry(P(ARTP) = 0.038). BMI did not modify these associations.

conclusionsOur data support our hypothesis that certain EH genes influence survival after diagnosis with breast cancer; associations appear to be most important among women with low NA ancestry.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAgedAged, 80 and overBreast NeoplasmsCase-Control StudiesCholecystokininEnergy MetabolismFemaleGenotypeHispanic or LatinoHomeostasisHumansMiddle AgedNeuropeptide YCholecystokininNeuropeptide YReceptors, GhrelinReceptors, Leptin

Identifiers

PMID26472474
PMCPMC4833710
OpenAlexW1957567082

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.