ArticleScientific reports2015
DNA methylation Landscape of body size variation in sheep.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Genomic context determines the effect of DNA methylation on gene expression in the gut epithelium of Atlantic salmon (Epigenetics · 2024Article
- Article
- Genome-wide association studies of body size traits in Tibetan sheep.BMC genomics · 2024Article
- Effects of nonsynonymous single nucleotide polymorphisms of theFrontiers in veterinary science · 2024Article
- Identification of selective sweep and associated QTL traits in IranianFrontiers in genetics · 2024Article
- Screening Indels from the whole genome to identify the candidates and their association with economic traits in several goat breeds.Functional & integrative genomics · 2023Article
- Early fish domestication affects methylation of key genes involved in the rapid onset of the farmed phenotype.Epigenetics · 2022Article
- Genome-Wide DNA Methylation Patterns of Muscle and Tail-Fat in DairyMeade Sheep and Mongolian Sheep.Animals : an open access journal from MDPI · 2022Article
- Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds.BMC veterinary research · 2021Article
- Expression analysis and single-nucleotide polymorphisms ofArchives animal breeding · 2021Article
- Comparative whole genome DNA methylation profiling across cattle tissues reveals global and tissue-specific methylation patterns.BMC biology · 2020Article
- Genetic Determinism Exists for the Global DNA Methylation Rate in Sheep.Frontiers in genetics · 2020Article
- Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species.Epigenetics & chromatin · 2018Article
- Comparative whole genome DNA methylation profiling of cattle sperm and somatic tissues reveals striking hypomethylated patterns in sperm.GigaScience · 2018Article
- Article
- From forensic epigenetics to forensic epigenomics: broadening DNA investigative intelligence.Genome biology · 2017Article
- Combined GWAS and 'guilt by association'-based prioritization analysis identifies functional candidate genes for body size in sheep.Genetics, selection, evolution : GSE · 2017Article
- Reduced representation bisulphite sequencing of ten bovine somatic tissues reveals DNA methylation patterns and their impacts on gene expression.BMC genomics · 2016Article
- Genome-wide analysis of DNA methylation in obese, lean, and miniature pig breeds.Scientific reports · 2016Article
- Pleiotropic Genes Affecting Carcass Traits in Bos indicus (Nellore) Cattle Are Modulators of Growth.PloS one · 2016Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sub-populations of Chinese Mongolian sheep exhibit significant variance in body mass. In the present study, we sequenced the whole genome DNA methylation in these breeds to detect whether DNA methylation plays a role in determining the body mass of sheep by Methylated DNA immunoprecipitation - sequencing method. A high quality methylation map of Chinese Mongolian sheep was obtained in this study. We identified 399 different methylated regions located in 93 human orthologs, which were previously reported as body size related genes in human genome-wide association studies. We tested three regions in LTBP1, and DNA methylation of two CpG sites showed significant correlation with its RNA expression. Additionally, a particular set of differentially methylated windows enriched in the "development process" (GO: 0032502) was identified as potential candidates for association with body mass variation. Next, we validated small part of these windows in 5 genes; DNA methylation of SMAD1, TSC1 and AKT1 showed significant difference across breeds, and six CpG were significantly correlated with RNA expression. Interestingly, two CpG sites showed significant correlation with TSC1 protein expression. This study provides a thorough understanding of body size variation in sheep from an epigenetic perspective.
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