ArticleChemistry (Weinheim an der Bergstrasse, Germany)2015
Graphene Oxide Nanosheets Modified with Single-Domain Antibodies for Rapid and Efficient Capture of Cells.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer.MRS communications · 2022Review
- Graphene- and Graphene Oxide-Based Nanocomposite Platforms for Electrochemical Biosensing Applications.International journal of molecular sciences · 2019Review
- Applications of Nanosheets in Frontier Cellular Research.Nanomaterials (Basel, Switzerland) · 2018Review
- Current Conjugation Methods for Immunosensors.Nanomaterials (Basel, Switzerland) · 2018Review
- Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell.Biosensors & bioelectronics · 2017Article
- Enhanced Cell Capture on Functionalized Graphene Oxide Nanosheets through Oxygen Clustering.ACS nano · 2017Article
- Single-Domain Antibodies As Versatile Affinity Reagents for Analytical and Diagnostic Applications.Frontiers in immunology · 2017Review
- Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma.Angewandte Chemie (International ed. in English) · 2016Article
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Authors and funding
10 authors.
Funding
Abstract
Peripheral blood can provide valuable information on an individual's immune status. Cell-based assays typically target leukocytes and their products. Characterization of leukocytes from whole blood requires their separation from the far more numerous red blood cells.1 Current methods to classify leukocytes, such as recovery on antibody-coated beads or fluorescence-activated cell sorting require long sample preparation times and relatively large sample volumes.2 A simple method that enables the characterization of cells from a small peripheral whole blood sample could overcome limitations of current analytical techniques. We describe the development of a simple graphene oxide surface coated with single-domain antibody fragments. This format allows quick and efficient capture of distinct WBC subpopulations from small samples (∼30 μL) of whole blood in a geometry that does not require any specialized equipment such as cell sorters or microfluidic devices.
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