ArticlePlant physiology2015
Changes in the Phosphoproteome and Metabolome Link Early Signaling Events to Rearrangement of Photosynthesis and Central Metabolism in Salinity and Oxidative Stress Response in Arabidopsis.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 77 citations in OpenAlex.
- Quantitative phosphoproteomics profiling reveals the regulatory mechanisms underlying high light stress in maize and rice.Photosynthesis research · 2026Article
- Protein Post-Translational Modifications in Plant Abiotic Stress Responses.Plants (Basel, Switzerland) · 2025Review
- OsSSID6 Negatively Regulates Salt Stress Tolerance in Rice (Oryza Sativa L.) via Metabolic Pathways and ROS Scavenging.Rice (New York, N.Y.) · 2025Article
- Antioxidant Defense Systems in Plants: Mechanisms, Regulation, and Biotechnological Strategies for Enhanced Oxidative Stress Tolerance.Life (Basel, Switzerland) · 2025Review
- Unveiling oxidative stress: surface ozone triggers phenylpropanoid pathway shifts and metabolite rewiring in PBW-550 wheat.Plant cell reports · 2025Article
- Revisiting the role of light signaling in plant responses to salt stress.Horticulture research · 2025Article
- Article
- Plant Life with and without Oxygen: A Metabolomics Approach.International journal of molecular sciences · 2023Review
- Reversible protein phosphorylation in higher plants: focus on state transitions.Biophysical reviews · 2023Review
- Article
- Receptor for Activated C Kinase1B (RACK1B) Delays Salinity-Induced Senescence in Rice Leaves by Regulating Chlorophyll Degradation.Plants (Basel, Switzerland) · 2023Article
- Physiological and Transcriptional Responses ofInternational journal of molecular sciences · 2023Article
- SnRK2.10 kinase differentially modulates expression of hub WRKY transcription factors genes under salinity and oxidative stress inFrontiers in plant science · 2023Article
- Application of Magnesium and Calcium Sulfate on Growth and Physiology of Forage Crops under Long-Term Salinity Stress.Plants (Basel, Switzerland) · 2022Article
- Transcriptomic Analysis of Mature Transgenic Poplar Expressing the Transcription FactorFrontiers in bioengineering and biotechnology · 2022Article
- Regulation of Plant Responses to Salt Stress.International journal of molecular sciences · 2021Review
- Oxidative Stress-Induced Alteration of Plant Central Metabolism.Life (Basel, Switzerland) · 2021Review
- Mapping Plant Phosphoproteome with Improved Tandem MOAC and Label-Free Quantification.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Comparative Proteomics Analysis Reveals Unique Early Signaling Response ofInternational journal of molecular sciences · 2020Article
- Large-Scale Phosphoproteomic Study ofInternational journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salinity and oxidative stress are major factors affecting and limiting the productivity of agricultural crops. The molecular and biochemical processes governing the plant response to abiotic stress have often been researched in a reductionist manner. Here, we report a systemic approach combining metabolic labeling and phosphoproteomics to capture early signaling events with quantitative metabolome analysis and enzyme activity assays to determine the effects of salt and oxidative stress on plant physiology. K(+) and Na(+) transporters showed coordinated changes in their phosphorylation pattern, indicating the importance of dynamic ion homeostasis for adaptation to salt stress. Unique phosphorylation sites were found for Arabidopsis (Arabidopsis thaliana) SNF1 kinase homolog10 and 11, indicating their central roles in the stress-regulated responses. Seven Sucrose Non-fermenting1-Related Protein Kinase2 kinases showed varying levels of phosphorylation at multiple serine/threonine residues in their kinase domain upon stress, showing temporally distinct modulation of the various isoforms. Salinity and oxidative stress also lead to changes in protein phosphorylation of proteins central to photosynthesis, in particular the kinase State Transition Protein7 required for state transition and light-harvesting II complex proteins. Furthermore, stress-induced changes of the phosphorylation of enzymes of central metabolism were observed. The phosphorylation patterns of these proteins were concurrent with changes in enzyme activity. This was reflected by altered levels of metabolites, such as the sugars sucrose and fructose, glycolysis intermediates, and amino acids. Together, our study provides evidence for a link between early signaling in the salt and oxidative stress response that regulates the state transition of photosynthesis and the rearrangement of primary metabolism.
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