ArticleScientific reports2015
Three-dimensional chemotaxis-driven aggregation of tumor cells.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Directed migration of cancer cells: a systems biophysics perspective.Frontiers in cell and developmental biology · 2026Review
- Trade-offs in concentration sensing in dynamic environments.Biophysical journal · 2024Article
- Collective directional migration drives the formation of heteroclonal cancer cell clusters.Molecular oncology · 2023Article
- Chemotactic smoothing of collective migration.eLife · 2022Article
- Dissecting Breast Cancer Circulating Tumor Cells Competence via Modelling Metastasis in Zebrafish.International journal of molecular sciences · 2021Article
- AQP3 Increases Intercellular Cohesion in NSCLC A549 Cell Spheroids through Exploratory Cell Protrusions.International journal of molecular sciences · 2021Article
- An Integrative and Modular Framework to Recapitulate Emergent Behavior in Cell Migration.Frontiers in cell and developmental biology · 2020Article
- A Tumor-on-a-Chip System with Bioprinted Blood and Lymphatic Vessel Pair.Advanced functional materials · 2019Article
- Effect of circulating tumor cell aggregate configuration on hemodynamic transport and wall contact.Mathematical biosciences · 2017Article
- Tissue Extract Fractions from Starfish Undergoing Regeneration Promote Wound Healing and Lower Jaw Blastema Regeneration of Zebrafish.Scientific reports · 2016Article
- The Cohesive Metastasis Phenotype in Human Prostate Cancer.Biochimica et biophysica acta · 2016Review
- Collective Chemotaxis through Noisy Multicellular Gradient Sensing.Biophysical journal · 2016Article
- ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most important steps in tumor progression involves the transformation from a differentiated epithelial phenotype to an aggressive, highly motile phenotype, where tumor cells invade neighboring tissues. Invasion can occur either by isolated mesenchymal cells or by aggregates that migrate collectively and do not lose completely the epithelial phenotype. Here, we show that, in a three-dimensional cancer cell culture, collective migration of cells eventually leads to aggregation in large clusters. We present quantitative measurements of cluster velocity, coalescence rates, and proliferation rates. These results cannot be explained in terms of random aggregation. Instead, a model of chemotaxis-driven aggregation - mediated by a diffusible attractant - is able to capture several quantitative aspects of our results. Experimental assays of chemotaxis towards culture conditioned media confirm this hypothesis. Theoretical and numerical results further suggest an important role for chemotactic-driven aggregation in spreading and survival of tumor cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.