ArticleThe Journal of orthopaedic and sports physical therapy2015
Quadriceps Strength, Muscle Activation Failure, and Patient-Reported Function at the Time of Return to Activity in Patients Following Anterior Cruciate Ligament Reconstruction: A Cross-sectional Study.
Article in The Journal of orthopaedic and sports physical therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01555567 (Quadriceps Inhibition After ACL Injury), which is not on this map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Quadriceps Inhibition After ACL Injury: Neuromuscular and Functional Consequences
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Assessment of Quadriceps Corticomotor and Spinal-Reflexive Excitability in Individuals with a History of Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Pooled it
- Enhanced recovery after surgery combined with quantitative rehabilitation training in early rehabilitation after total knee replacement: a randomized controlled trial.European journal of physical and rehabilitation medicine · 2024Trial
- Trial
- Contribution of Neuromuscular Factors to Quadriceps Asymmetry After Anterior Cruciate Ligament Reconstruction.Journal of athletic training · 2018Trial
- Young athletes after ACL reconstruction with quadriceps strength asymmetry at the time of return-to-sport demonstrate decreased knee function 1 year later.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Trial
- Association Between Interlimb Asymmetry in Normalized Vastus Medialis sEMG Amplitude and Functional Mobility in Patients with Post-Traumatic Knee Contracture: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Muscle atrophy after ACL reconstruction involves molecular mechanisms beyond unloading.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Effects of Transcranial Neuromodulation on Rehabilitation Outcomes After Anterior Cruciate Ligament Injury: A Systematic Review of Randomized Controlled Trials.Biomedicines · 2025Review
- Think Outside the Block: Rehabilitation Continuum After ACL Reconstruction with Adaptive Macro-Blocks-A Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Evaluation of eccentric and concentric force during vertical jump after anterior cruciate ligament reconstruction: a comparative study.BMC sports science, medicine & rehabilitation · 2025Article
- Dynamic change of direction, isometric strength, and psychological readiness in final phase ACLR athletes: an integrated approach.BMC musculoskeletal disorders · 2025Article
- Influence of Graft Type on Muscle Contractile Dynamics After ACL Reconstruction: A 9-Month Tensiomyographic Follow-Up.Diagnostics (Basel, Switzerland) · 2025Article
- Criteria-Based Decision Making for Introducing Open Kinetic Chain Exercise after-ACL Reconstruction: A Scoping Review.Sports medicine - open · 2025Review
- Rethinking the Assessment of Arthrogenic Muscle Inhibition After ACL Reconstruction: Implications for Return-to-Sport Decision-Making-A Narrative Review.Journal of clinical medicine · 2025Review
- Neuromuscular Control Deficits After Anterior Cruciate Ligament Reconstruction: A Pilot Study Using Single-Leg Functional Tests and Electromyography.Journal of functional morphology and kinesiology · 2025Article
- Muscle-specific ERRγ activation mitigates muscle atrophy after ACL injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Patients Who Do Not Achieve 90% of the Nonoperative Side on the Anterior Reach Y-Balance Test at 3 Months After ACL Reconstruction Are More Likely to Have Persistent Knee Extension Strength Asymmetry at 6 Months Postoperatively.International journal of sports physical therapy · 2025Article
- Acute effects of eccentric overload training with different loading doses in male sprinters.Heliyon · 2024Article
- A Portable, Neurostimulation-Integrated, Force Measurement Platform for the Clinical Assessment of Plantarflexor Central Drive.Bioengineering (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
designCross-sectional.
objectivesTo determine if quadriceps activation failure (QAF) moderates the relationship between quadriceps strength and physical function in individuals following anterior cruciate ligament (ACL) reconstruction.
backgroundQuadriceps activation failure may impair the recovery of physical function after ACL reconstruction, given that QAF reduces strength and strength is related to physical function. Evidence of this relationship has been found in individuals with knee osteoarthritis, wherein patients with lower strength and greater QAF had lower levels of physical function.
methodsParticipants consisted of 52 individuals who were cleared for return to activity at an average ± SD of 7.4 ± 1.2 months post-ACL reconstruction. Quadriceps activation failure was assessed using the superimposed burst technique, and quadriceps strength was assessed using concentric isokinetic contractions (Newton meters per kilogram). Physical function was quantified using a combined variable of a physical measure (single-leg hop for distance) and a self-reported function measure (International Knee Documentation Committee [IKDC] Subjective Knee Evaluation Form), calculated using a principal-component analysis. Simple correlations were then performed to determine the order in which variables were entered into the regression model to evaluate if QAF moderates the relationship between quadriceps strength and physical function.
resultsThe combination of quadriceps strength and the interaction of strength by QAF predicted 30% of the variance in physical function (R(2) = 0.30, P<.001; principal-component analysis, -0.61(strength) + 0.02(interaction) -1.896); however, the interaction of strength by QAF only accounted for 7% of the capabilities of the model (P = .023).
conclusionPhysical function is largely influenced by the recovery of quadriceps strength and minimally attenuated by QAF. These data suggest that QAF may affect individuals post-ACL reconstruction differently, and to a lesser extent, than individuals with knee osteoarthritis. This trial was prospectively registered in a public registry (NCT01555567).
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.