ArticleMolecular brain2015
PARP-1 activity is required for the reconsolidation and extinction of contextual fear memory.
Article in Molecular brain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Synaptic potentiation requires PARP1 activation: prevailing concepts are revisited.Molecular psychiatry · 2026Review
- Poly ADP-ribosylation regulates Arc expression and promotes adaptive stress-coping.Psychopharmacology · 2025Article
- Pathobiochemistry of Aging and Neurodegeneration: Deregulation of NAD+ Metabolism in Brain Cells.Biomolecules · 2024Review
- Fear memory regulation by the cAMP signaling pathway as an index of reexperiencing symptoms in posttraumatic stress disorder.Molecular psychiatry · 2024Article
- Role of NADCellular and molecular neurobiology · 2023Review
- Role of posttranslational modifications in memory and cognitive impairments caused by neonatal sevoflurane exposure.Frontiers in pharmacology · 2023Review
- Pharmacological Modulation of TRPM2 Channels via PARP Pathway Leads to Neuroprotection in MPTP-induced Parkinson's Disease in Sprague Dawley Rats.Molecular neurobiology · 2022Article
- Prefrontal cortex, amygdala, and threat processing: implications for PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Modulation of PARP-1 Activity in a Broad Time Window Attenuates Memorizing Fear.International journal of molecular sciences · 2021Article
- Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation.GeroScience · 2021Article
- Phase Separation and Histone Epigenetics in Genome Regulation.Current opinion in solid state & materials science · 2021Article
- Article
- Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation.Nature communications · 2019Article
- Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment.Neural plasticity · 2019Article
- Cell Death Pathways: a Novel Therapeutic Approach for Neuroscientists.Molecular neurobiology · 2018Review
- Autophagy Enhances Memory Erasure through Synaptic Destabilization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory.Molecular brain · 2017Article
- Functional Connectivity of Multiple Brain Regions Required for the Consolidation of Social Recognition Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Epigenetic regulation and chromatin remodeling in learning and memory.Experimental & molecular medicine · 2017Review
- Vitamin B1-deficient mice show impairment of hippocampus-dependent memory formation and loss of hippocampal neurons and dendritic spines: potential microendophenotypes of Wernicke-Korsakoff syndrome.Bioscience, biotechnology, and biochemistry · 2016Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMemory consolidation, reconsolidation, and extinction have been shown to require new gene expression. Poly ADP-ribosylation mediated by poly (ADP-ribose) polymerase-1 (PARP-1) is known to regulate transcription through histone modification. Recent studies have suggested that PARP-1 positively regulates the formation of long-term memory (LTM); however, the roles of PARP-1 in memory processes, especially processes after retrieval, remain unknown.
resultsHere, we show critical roles for PARP-1 in the consolidation, reconsolidation, and extinction of contextual fear memory in mice. We examined the effects of pharmacological inhibition of PARP-1 activity in the hippocampus or medial prefrontal cortex (mPFC) on these memory processes. Similarly with previous findings, a micro-infusion of the PARP-1 inhibitor 3-aminobenzamide or PJ34 into the dorsal hippocampus, but not mPFC, impaired LTM formation without affecting short-term memory (STM). Importantly, this pharmacological blockade of PARP-1 in the dorsal hippocampus, but not mPFC, also disrupted post-reactivation LTM without affecting post-reactivation STM. Conversely, micro-infusion of the PARP-1 inhibitors into the mPFC, but not dorsal hippocampus, blocked long-term extinction. Additionally, systemic administration of the PARP-1 inhibitor Tiq-A blocked c-fos induction in the hippocampus, which is observed when memory is consolidated or reconsolidated, and also blocked c-fos induction in the mPFC, which is observed when memory is extinguished.
conclusionsOur observations showed that PARP-1 activation is required for the consolidation, reconsolidation, and extinction of contextual fear memory and suggested that PARP-1 contributes to the new gene expression necessary for these memory processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.