ArticleAJNR. American journal of neuroradiology2015
Effect of Collaterals on Clinical Presentation, Baseline Imaging, Complications, and Outcome in Acute Stroke.
Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Radiological predictors of hemorrhagic transformation after acute ischemic stroke: An evidence-based analysis.The neuroradiology journal · 2020Pooled it
- Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017.Stroke and vascular neurology · 2018Guideline
- Blood pressure in the first 6 hours for older adults with stroke after endovascular therapy: a pooled analysis of the DEVT and RESCUE BT randomized clinical trials.Journal of thrombosis and thrombolysis · 2026Trial
- Endovascular Thrombectomy in Medium and Distal Vessel Occlusions: A Focused Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee.Stroke (Hoboken, N.J.) · 2026Review
- Computational fluid dynamics assessment of altered hemodynamics in the Circle of Willis during acute ischemic stroke and the impact of cerebral collateral development.Biomechanics and modeling in mechanobiology · 2026Article
- Dual-phase CTA filling pattern is associated with reperfusion-related complications after mechanical thrombectomy in late-window anterior circulation stroke.Frontiers in medicine · 2026Article
- Prognostic value of collateral scoring systems for hemorrhagic transformation after endovascular treatment in acute ischemic stroke.Polish journal of radiology · 2026Article
- Intracerebral arterial blood pressure in the vasculature distal to large vessel occlusions in patients with ischemic stroke: correlation with clinical and imaging parameters.Journal of neurointerventional surgery · 2025Article
- Spatial and Temporal Assessment of Cerebral Blood Flow in a Novel Piglet Model of Neonatal Arterial Ischemic Stroke.Translational stroke research · 2025Article
- Correlation between collateral compensation of the posterior cerebral artery on 5 T magnetic resonance imaging and clinical classifications in patients with Moyamoya angiopathy.Japanese journal of radiology · 2025Article
- Comparative evaluation of 5.0 T and 3.0 T time-of-flight magnetic resonance angiography in assessing collateral circulation in moyamoya angiopathy.Cardiovascular diagnosis and therapy · 2025Article
- Automated assessment of collateral circulation and infarct core: predictors of functional outcomes in acute ischemic stroke following endovascular thrombectomy.Neuroradiology · 2025Article
- Efficacy of biomarkers and imaging techniques for the diagnosis of traumatic brain injury: challenges and opportunities.Molecular and cellular biochemistry · 2025Review
- Unfavorable venous outflow correlates with poor prognosis in acute ischemic stroke due to large vessel occlusion (AIS-LVO) patients assessed dynamically and quantitatively based on four-dimensional computed tomography angiography/perfusion (4D-CTA/CTP).Quantitative imaging in medicine and surgery · 2025Article
- Hypoperfusion Intensity Ratio Less Than 0.4 Is Associated with Favorable Outcomes in Unsuccessfully Reperfused Acute Ischemic Stroke with Large-Vessel Occlusion.AJNR. American journal of neuroradiology · 2025Article
- Hypoperfusion Intensity Ratio and Hemorrhagic Transformation in Patients with Successful Recanalization after Thrombectomy.AJNR. American journal of neuroradiology · 2024Article
- Mimicking aneurysm in a patient with chronic occlusion of the left middle cerebral artery: A case report.World journal of clinical cases · 2024Article
- Predicting 3-month Functional Outcome After Endovascular Thrombectomy in Patients with Anterior Circulation Occlusion with an Arterial Transit Artifact Grading System.Clinical neuroradiology · 2024Article
- Anatomical variations in the circle of Willis on magnetic resonance angiography in a south Trinidad population.BJR open · 2024Article
- Blood Pressure Control for Patients with Middle Cerebral Artery Severe Stenosis or Occlusion.Clinical interventions in aging · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeGood CTA collaterals independently predict good outcome in acute ischemic stroke. Our aim was to evaluate the role of collateral circulation and its added benefit over CTP-derived total ischemic volume as a predictor of baseline NIHSS score, total ischemic volume, hemorrhagic transformation, final infarct size, and a modified Rankin Scale score >2. MATERIALS AND
methodsThis was a retrospective study of 395 patients with stroke dichotomized by recanalization (recanalization positive/recanalization negative) and collateral status. Clot burden score was quantified on baseline CTA. Total ischemic volumes were derived from thresholded CTP maps. Final infarct size was assessed on follow-up CT/MRI. We performed uni-/multivariate analyses for each outcome, adjusting for rtPA status, using general linear (continuous variables) and logistic (binary variables) regression. Model comparison with collateral score and total ischemic volume was performed using the F or likelihood ratio test.
resultsCollateral presence independently and inversely predicted all outcomes except hemorrhagic transformation in patients who were recanalization negative and mRS >2 in patients who were recanalization positive. The greatest collateral benefit occurred in patients who were recanalization negative, contributing 16.5% and 19.2% of the variability for final infarct size and mRS >2. The collateral score model is superior to the total ischemic volume for mRS >2 prediction, but a combination of total ischemic volume and collateral score is superior for mRS >2 and final infarct prediction (24% and 28% variability, respectively). In patients who were recanalization positive, a model including collateral score and total ischemic volume was superior to that of total ischemic volume for hemorrhagic transformation and final infarct prediction but was muted compared with patients who were recanalization negative (11.3% and 16.9% variability).
conclusionsCollateral circulation is an independent predictor of all outcomes, but the magnitude of significance varies, greater in patients who were recanalization negative versus recanalization positive. Total ischemic volume assessment is complementary to collateral score in many cases.
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