Evidence map›Paper›PMID 26471514›Full record

ArticleMagnetic resonance imaging2016

Isotropic 3D black blood MRI of abdominal aortic aneurysm wall and intraluminal thrombus.

Chengcheng Zhu, Henrik Haraldsson, Farshid Faraji, Christopher Owens, Warren Gasper, Sinyeob Ahn, Jing Liu, Gerhard Laub, Michael D Hope, David Saloner

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
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  5. Dark blood cardiovascular magnetic resonance of the heart, great vessels, and lungs using electrocardiographic-gated three-dimensional unbalanced steady-state free precession.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
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  11. Surveillance of abdominal aortic aneurysm using accelerated 3D non-contrast black-blood cardiovascular magnetic resonance with compressed sensing (CS-DANTE-SPACE).Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019
    Article
  12. Article
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  16. Observational
  17. Black-blood thrombus imaging (BTI): a contrast-free cardiovascular magnetic resonance approach for the diagnosis of non-acute deep vein thrombosis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chengcheng ZhuDepartment of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA. Electronic address: Chengcheng.Zhu@ucsf.edu.
Henrik HaraldssonDepartment of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA.
Farshid FarajiDepartment of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA.
Christopher OwensVascular Surgery Service, VA Medical Center, San Francisco, USA.
Warren GasperVascular Surgery Service, VA Medical Center, San Francisco, USA.
Sinyeob AhnSiemens Healthcare, CA, USA.
Jing LiuDepartment of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA.
Gerhard LaubSiemens Healthcare, CA, USA.
Michael D HopeDepartment of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA.
David SalonerDepartment of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA; Radiology Service, VA Medical Center, San Francisco, USA.
San Francisco VA Medical Center · USSiemens Healthcare (United States) · USUniversity of California, San Francisco · US

Funding

MRI of Structure and Function in Assessing Hemodynamic Impact on AAA EvolutionR01HL114118 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SALONER, DAVID A · 2014 to 2017
$1.8M
Determinants of Intracranial Aneurysm GrowthR01NS059944 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALONER, DAVID A · 2009 to 2013
$1.7M
Hemodynamic and inflammatory imaging in evaluation of abdominal aortic aneurysmsR01HL123759 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOPE, MICHAEL DOUGLAS · 2015 to 2018
$1.6M
4D MRI Development for Cardiovascular ImagingK25EB014914 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIU, JING · 2012 to 2016
$842k
NHLBI NIH HHS R01 HL114118NHLBI NIH HHS R01HL114118NHLBI NIH HHS R01 HL123759NHLBI NIH HHS R01HL123759NIBIB NIH HHS K25 EB014914NINDS NIH HHS R01 NS059944NINDS NIH HHS R01NS059944
6 · The paper itself

Abstract

introductionThe aortic wall and intraluminal thrombus (ILT) have been increasingly studied as potential markers of progressive disease with abdominal aortic aneurysms (AAAs). Our goal was to develop a high resolution, 3D black blood MR technique for AAA wall and ILT imaging within a clinically acceptable scan time.

methodsTwenty two patients with AAAs (maximal diameter 4.3±1.0cm), along with five healthy volunteers, were imaged at 3T with a 3D T1-weighted fast-spin-echo sequence using variable flip angle trains (SPACE) with a preparation pulse (DANTE) for suppressing blood signal. Volunteers and ten patients were also scanned with SPACE alone for comparison purposes. The signal to noise ratio (SNR) and the aortic wall/ILT to lumen contrast to noise ratio (CNR) were measured. Qualitative image scores (1-4 scale) assessing the inner lumen and outer wall boundaries of AAA were performed by two blinded reviewers. In patients with ILT, the ratio of ILT signal intensity (ILTSI) over psoas muscle SI (MuscleSI) was calculated, and the signal heterogeneity of ILT was quantified as standard deviation (SD) over the mean.

resultsAll subjects were imaged successfully with an average scan time of 7.8±0.7minutes. The DANTE preparation pulse for blood suppression substantially reduced flow artifacts in SPACE with lower lumen SNR (8.8 vs. 21.4, p<0.001) and improved the wall/ILT to lumen CNR (9.9 vs. 6.3, p<0.001) in patients. Qualitative assessment showed improved visualization of lumen boundaries (73% higher scores on average, p=0.01) and comparable visualization of outer wall boundary (p>0.05). ILT was present in ten patients, with relatively high signal and a wide SD (average ILTSI/MuscleSI 1.42±0.48 (range 0.75-2.11)) and with SD/mean of 27.7%±6.6% (range 19.6%-39.4%).

conclusionHigh resolution, 3D black blood MRI of AAAs can be achieved in a clinical accepted scan time with reduction of flow artifacts using the DANTE preparation pulse. Signal characteristics of ILT can be quantified and may be used for improved patient-specific risk stratification.

Indexed as

AgedAlgorithmsAnisotropyAortic Aneurysm, AbdominalAortic Valve StenosisHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance AngiographyMaleReproducibility of ResultsSensitivity and SpecificityThrombosis3D black bloodAbdominal aortic aneurysmBlood suppressionIntra-luminal thrombusVessel wall MRI

Identifiers

PMID26471514
PMCPMC4691394
OpenAlexW2219299837

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.