Evidence map›Paper›PMID 26471486›Full record

ArticleHaematologica2016

Molecular subtypes of NPM1 mutations have different clinical profiles, specific patterns of accompanying molecular mutations and varying outcomes in intermediate risk acute myeloid leukemia.

Tamara Alpermann, Susanne Schnittger, Christiane Eder, Frank Dicker, Manja Meggendorfer, Wolfgang Kern, Christoph Schmid, Carlo Aul, Peter Staib, Clemens-Martin Wendtner and 3 more

Abstract readLetter
In one paragraph

Article in Haematologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. NPM1 Measurable Residual Disease: A Narrative Review.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Review
  3. Article
  4. Cancers · 2025
    Review
  5. Influence of Nucleophosmin (Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Targeting and Monitoring Acute Myeloid Leukaemia with Nucleophosmin-1 (International journal of molecular sciences · 2023
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tamara AlpermannMLL Munich Leukemia Laboratory, Klinikum Augsburg, University of Munich, Augsburg, Germany.
Susanne SchnittgerMLL Munich Leukemia Laboratory, Klinikum Augsburg, University of Munich, Augsburg, Germany.
Christiane EderMLL Munich Leukemia Laboratory, Klinikum Augsburg, University of Munich, Augsburg, Germany.
Frank DickerMLL Munich Leukemia Laboratory, Klinikum Augsburg, University of Munich, Augsburg, Germany.
Manja MeggendorferMLL Munich Leukemia Laboratory, Klinikum Augsburg, University of Munich, Augsburg, Germany.
Wolfgang KernMLL Munich Leukemia Laboratory, Klinikum Augsburg, University of Munich, Augsburg, Germany.
Christoph SchmidDepartment of Hematology and Oncology, Klinikum Augsburg, University of Munich, Augsburg, Germany.
Carlo AulDepartment of Hematology and Oncology, Helios St. Johannes Klinik, Duisburg, Germany.
Peter StaibDepartment of Hematology and Oncology, St. Antonius Hospital, Eschweiler, Germany.
Clemens-Martin WendtnerDepartment of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases and Tropical Medicine, Klinikum Schwabing, Munich, Germany.
Norbert SchmitzDepartment of Hematology, Oncology and Stem Cell Transplantation, Asklepios Klinik St. Georg, Hamburg, Germany.
Claudia HaferlachMLL Munich Leukemia Laboratory, Klinikum Augsburg, University of Munich, Augsburg, Germany.
Torsten HaferlachMLL Munich Leukemia Laboratory, Klinikum Augsburg, University of Munich, Augsburg, Germany torsten.haferlach@mll.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationAdolescentAdultAgedAged, 80 and overCCAAT-Enhancer-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Mutational AnalysisFemalefms-Like Tyrosine Kinase 3Gene ExpressionGene Expression ProfilingHumansIsocitrate DehydrogenaseLeukemia, Myeloid, AcuteCCAAT-Enhancer-Binding ProteinsCEBPA protein, humanDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanFLT3 protein, humanfms-Like Tyrosine Kinase 3IDH1 protein, humanIDH2 protein, humanIsocitrate DehydrogenaseNeoplasm ProteinsNPM1 protein, humanNuclear ProteinsNucleophosminOncogene Proteins, FusionWT1 protein, humanWT1 ProteinsAMLDNMT3A mutationFLT3-ITDmolecular geneticsNPM1 mutationprognosis

Identifiers

PMID26471486
PMCPMC4938334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.