ArticleScientific reports2015
Development and external validation of a prostate health index-based nomogram for predicting prostate cancer.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Trial
- Nomogram Using Prostate Health Index for Predicting Prostate Cancer in the Gray Zone: Prospective, Multicenter Study.The world journal of men's health · 2024Article
- The influence of age on prostate cancer screening index.Journal of clinical laboratory analysis · 2022Article
- Personalized strategies in population screening for prostate cancer.International journal of cancer · 2020Review
- Correlation between Gleason score distribution and Prostate Health Index in patients with prostate-specific antigen values of 2.5-10 ng/mL.Investigative and clinical urology · 2020Article
- A novel nomogram predicting the risk of positive biopsy for patients in the diagnostic gray area of prostate cancer.Scientific reports · 2020Article
- Adaptation of the prostate biopsy collaborative group risk calculator in patients with PSA less than 10 ng/ml improves its performance.International urology and nephrology · 2020Article
- The prediction value of PI-RADS v2 score in high-grade Prostate Cancer: a multicenter retrospective study.International journal of medical sciences · 2020Article
- Early Diagnosis of Prostate Cancer from the Perspective of Chinese Physicians.Journal of Cancer · 2020Review
- Prostate health index is useful for prostate cancer detecting in Chinese people.Translational cancer research · 2019Article
- Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese population.Asian journal of andrologyObservational
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
To develop and externally validate a prostate health index (PHI)-based nomogram for predicting the presence of prostate cancer (PCa) at biopsy in Chinese men with prostate-specific antigen 4-10 ng/mL and normal digital rectal examination (DRE). 347 men were recruited from two hospitals between 2012 and 2014 to develop a PHI-based nomogram to predict PCa. To validate these results, we used a separate cohort of 230 men recruited at another center between 2008 and 2013. Receiver operator curves (ROC) were used to assess the ability to predict PCa. A nomogram was derived from the multivariable logistic regression model and its accuracy was assessed by the area under the ROC (AUC). PHI achieved the highest AUC of 0.839 in the development cohort compared to the other predictors (p < 0.001). Including age and prostate volume, a PHI-based nomogram was constructed and rendered an AUC of 0.877 (95% CI 0.813-0.938). The AUC of the nomogram in the validation cohort was 0.786 (95% CI 0.678-0.894). In clinical effectiveness analyses, the PHI-based nomogram reduced unnecessary biopsies from 42.6% to 27% using a 5% threshold risk of PCa to avoid biopsy with no increase in the number of missed cases relative to conventional biopsy decision.
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