Evidence map›Paper›PMID 26471235›Full record

Observational studyHarm reduction journal2015

Impact of a methadone maintenance therapy pilot in Vietnam and its role in a scaled-up response.

Tran Vu Hoang, Tran Thi Thanh Ha, Tran Minh Hoang, Nguyen To Nhu, Nguyen Cuong Quoc, Nguyen thi Minh Tam, Stephen Mills

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in Harm reduction journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04706624 (Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04706624 nacompletednot on this mapstarted 2021, after this paper: background citation

Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics

TypeinterventionalSponsorHanoi Medical UniversityRan2021 to 2025Enrolled667ConditionsMethamphetamine Abuse, Opioid-use Disorder, HIV SeropositivityArmsContingency management (12 weeks), Contingency management (6 weeks), SMS reminders, Matrix only, Matrix + Contingency management
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Tran Vu HoangPartners in Health Research, 47 Yen Phu Street, Tay Ho District, Hanoi, Vietnam. Hoang@phr.com.vn.
Tran Thi Thanh HaFHI 360, 7th floor, Hanoi Tourist Building, 8 Ly Thuong Kiet Street, Hanoi, Vietnam. hatranthanh@yahoo.com.
Tran Minh HoangHanoi Medical University, No. 1, Ton That Tung Street, Hanoi, Vietnam. tranminhhoang123@gmail.com.
Nguyen To NhuFHI 360, 7th floor, Hanoi Tourist Building, 8 Ly Thuong Kiet Street, Hanoi, Vietnam. tonhu@fhi360.org.
Nguyen Cuong QuocFHI 360, 7th floor, Hanoi Tourist Building, 8 Ly Thuong Kiet Street, Hanoi, Vietnam. Quoc@fhi360.org.
Nguyen thi Minh TamVietnam Administration for AIDS Control, Vietnam Ministry of Health, 5th floor, 138a Giang Vo Street, Ba Dinh District, Hanoi, Vietnam. minhtam71@yahoo.com.
Stephen MillsFHI 360, 19th Floor, Sindhorn Building, Wittayu Road, Bangkok, Thailand. Smills@fhi360.org.
Family Health International 360 · USCenter for Creative Initiatives in Health and Population · VNHanoi Medical University · VNMinistry of Health · VN

Funding

PEPFAR 486-A-00-06-00009-00PEPFAR 486-A-11-00011
6 · The paper itself

Abstract

backgroundAs a dual response to the HIV epidemic and the high level of injecting drug use in Vietnam, the Ministry of Health (MOH) initiated a pilot methadone maintenance therapy (MMT) program in Hai Phong and Ho Chi Minh City (HCMC) in early 2009. The objectives of the pilot were to provide evidence on whether MMT could be successfully implemented in Vietnam and scaled up to other localities.

methodsA prospective study was conducted among 965 opiate drug users admitted to the pilot. Data on demographic characteristics, sexual behaviors, substance use behaviors (including heroin use), and blood-borne virus infection (HIV, hepatitis B, and hepatitis C) were collected at treatment initiation and then again at 3-, 6-, 9-, 12-, 18-, and 24-month intervals thereafter.

resultsTwenty-four months after treatment initiation, heroin use as measured by urine test or self-report had reduced from 100 % of participants at both sites to 14.6 % in Hai Phong and 22.9 % in HCMC. When adjusted for multiple factors in Generalized Estimating Equations (GEE) logistic regression modeling, independent predictors of continued heroin use after 24 months of MMT in HCMC were the following: poor methadone adherence (adjusted odds ratio (AOR) = 3.7, 95 % confidence interval (CI) 1.8-7.8); currently on antiretroviral treatment (ART) (AOR = 1.8, 95 % CI 1.4-2.4); currently on TB treatment (AOR = 2.2, 95 % CI 1.4-3.4); currently experiencing family conflict (AOR = 1.6, 95 % CI 1.1-2.4); and currently employed (AOR = 0.8, 95 % CI 0.6-1.0). For Hai Phong participants, predictors were the following: currently on ART (AOR = 2.0, 95 % CI = 1.4-3.0); currently experiencing family conflict (AOR = 2.0, 95 % CI = 1.0-3.9); and moderate adherence to methadone (AOR = 2.1, 95 % CI = 1.2-1.9). In Hai Phong, the percentage of participants who were employed had also increased by end of study from 35.0 to 52.8 %, while in HCMC the level remained relatively unchanged, between 52.2 and 55.1 %. DISCUSSION: Study findings were used in multiple fora to convince policymakers and the public on the significant and vital role MMT can play in reducing heroin use and improving quality of life for individuals and families. Four years after this study was completed, Vietnam had expanded MMT to 162 clinics in 44 provinces serving 32,000 patients.

Indexed as

AdultCohort StudiesFemaleFollow-Up StudiesHeroin DependenceHIV InfectionsHumansMaleMethadoneNarcoticsOpiate Substitution TreatmentPilot ProjectsProspective StudiesQuality of LifeSubstance Abuse, IntravenousVietnamMethadoneNarcotics

Identifiers

PMID26471235
PMCPMC4608299
OpenAlexW2135315351

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.