ArticleTrends in cell biology2015
Why Build Whole-Cell Models?
Article in Trends in cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Data hazards in synthetic biology.Synthetic biology (Oxford, England) · 2024Review
- Technologies for whole-cell modeling: Genome-wide reconstruction of a cell in silico.Development, growth & differentiation · 2023Review
- Predicting ecosystem metaphenome from community metagenome: A grand challenge for environmental biology.Ecology and evolution · 2023Article
- What's next for computational systems biology?Frontiers in systems biology · 2023Review
- Towards modelling emergence in plant systems.Quantitative plant biology · 2023Article
- Docking-based long timescale simulation of cell-size protein systems at atomic resolution.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Integrative modeling of the cell.Acta biochimica et biophysica Sinica · 2022Review
- A scalable, open-source implementation of a large-scale mechanistic model for single cell proliferation and death signaling.Nature communications · 2022Article
- Construction of Multiscale Genome-Scale Metabolic Models: Frameworks and Challenges.Biomolecules · 2022Review
- Challenges and opportunities in network-based solutions for biological questions.Briefings in bioinformatics · 2022Article
- Article
- The E. coli Whole-Cell Modeling Project.EcoSal Plus · 2021Article
- Modular assembly of dynamic models in systems biology.PLoS computational biology · 2021Article
- Atlas: automatic modeling of regulation of bacterial gene expression and metabolism using rule-based languages.Bioinformatics (Oxford, England) · 2021Article
- Hybrid modelling of biological systems using fuzzy continuous Petri nets.Briefings in bioinformatics · 2021Article
- When Is an In Silico Representation a Digital Twin? A Biopharmaceutical Industry Approach to the Digital Twin Concept.Advances in biochemical engineering/biotechnology · 2021Article
- Prediction of Cellular Burden with Host-Circuit Models.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Simultaneous cross-evaluation of heterogeneousScience (New York, N.Y.) · 2020Article
- Art and Science of the Cellular Mesoscale.Trends in biochemical sciences · 2020Review
- Computer-Aided Whole-Cell Design: Taking a Holistic Approach by Integrating Synthetic With Systems Biology.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Our ability to build computational models that account for all known gene functions in a cell has increased dramatically. But why build whole-cell models, and how can they best be used? In this forum, we enumerate several areas in which whole-cell modeling can significantly impact research and technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.