ArticleBMC complementary and alternative medicine2015
Antimalarial activity of 80 % methanolic extract of Brassica nigra (L.) Koch. (Brassicaceae) seeds against Plasmodium berghei infection in mice.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature.Malaria journal · 2021Pooled it
- Bacterial diversity, quantitative risk assessment of spring waterborne pathogens and their biocontrol through phyto-biosorbents.PloS one · 2026Article
- Overview of Phytochemical Composition ofFoods (Basel, Switzerland) · 2024Review
- Review
- Medicinal plants used in traditional treatment of malaria in Ethiopia: a review of ethnomedicine, anti-malarial and toxicity studies.Malaria journal · 2022Review
- Antimalarial Activity of Crude Extract and Solvent Fractions of Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Article
- Evaluation of Antimalarial Activity of 80% Methanolic Root Extract ofClinical pharmacology : advances and applications · 2021Article
- Article
- Antimalarial Effect of the Root ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Anti-malarial activity of the root extract of Euphorbia abyssinica (Euphorbiaceae) against Plasmodium berghei infection in mice.Malaria journal · 2019Article
- Antimalarial Activity ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Treatments used for malaria in young Ethiopian children: a retrospective study.Malaria journal · 2018Article
- Antiplasmodial activity of two medicinal plants against clinical isolates ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Article
- Antimalarial and cytotoxic activities of roots and fruits fractions ofIranian journal of basic medical sciences · 2017Article
- Antiplasmodial activity of Indigofera spicata root extract against Plasmodium berghei infection in mice.Malaria journal · 2017Article
- THERAPEUTIC POTENTIALS OF ETHANOLIC EXTRACT OF LEAVES OFAfrican journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Article
- Antimalarial Activity of Seed Extracts ofJournal of evidence-based integrative medicineArticle
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResistances to currently available drugs and insecticides, significant drug toxicities and costs and lack of vaccines currently complicated the treatment of malaria. A continued search for safe, effective and affordable plant-based antimalarial agents thus becomes crucial and vital in the face of these difficulties. The aim of the study was to evaluate the antimalarial activity of 80 % methanolic extract of the seeds of Brassica nigra against Plasmodium berghei infection in mice.
methodChloroquine sensitive Plasmodium berghei (ANKA strain) was used to test the antimalarial activity of the extract. In suppressive and prophylactic models, Swiss albino male mice were randomly grouped into five groups of five mice each. Group I mice were treated with the vehicle, group II, III and IV were treated with 100, 200, and 400 mg/kg of the extract, respectively and the last group (V) mice were treated with chloroquine (10 mg/kg). The level of parasitemia, survival time and variation in weight of mice were used to determine the antimalarial activity of the extract.
resultsChemosuppressive activities produced by the extract of the seeds of Brassica nigra were 21.88, 50.00 (P < 0.01) and 53.13 % (P < 0.01), while the chemoprophylactic activities were 17.42, 21.21 and 53.79 % (P < 0.05) at 100, 200 and 400 mg/kg of the extract, respectively as compared to the negative control. Mice treated with 200 and 400 mg/kg extract were significantly (P < 0.05) lived longer and gained weight as compared to negative control in 4-day suppressive test.
conclusionFrom this study, it can be concluded that the seed extract of Brassica nigra showed good chemosuppressive and moderate chemoprophylactic activities and the plant may contain biologically active principles which are relevant in the treatment and prophylaxis of malaria, thus supporting further studies of the plant for its active components.
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