ArticleScientific reports2015
Oscillating high-aspect-ratio monolithic silicon nanoneedle array enables efficient delivery of functional bio-macromolecules into living cells.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Geometry-Tunable Nanoneedle Arrays Reveal Membrane Penetration Mechanics for Intracellular Delivery.Biosensors · 2026Article
- Direct protein delivery into intact Arabidopsis cells for genome engineering.Scientific reports · 2024Article
- Nanoinjection: A Platform for Innovation in Ex Vivo Cell Engineering.Accounts of chemical research · 2024Article
- Status and developmental trends in recombinant collagen preparation technology.Regenerative biomaterials · 2024Review
- Electroactive nanoinjection platform for intracellular delivery and gene silencing.Journal of nanobiotechnology · 2023Article
- Microneedles in Advanced Microfluidic Systems: A Systematic Review throughout Lab and Organ-on-a-Chip Applications.Pharmaceutics · 2023Review
- Role of actin cytoskeleton in cargo delivery mediated by vertically aligned silicon nanotubes.Journal of nanobiotechnology · 2022Article
- Polysaccharide-Polyplex Nanofilm Coatings Enhance Nanoneedle-Based Gene Delivery and Transfection Efficiency.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Semi-Implantable Bioelectronics.Nano-micro letters · 2022Review
- Microfluidic mechanoporation for cellular delivery and analysis.Materials today. Bio · 2022Review
- Microneedle Array-Assisted, Direct Delivery of Genome-Editing Proteins Into Plant Tissue.Frontiers in plant science · 2022Article
- Tutorial: using nanoneedles for intracellular delivery.Nature protocols · 2021Review
- Cell penetration efficiency analysis of different atomic force microscopy nanoneedles into living cells.Scientific reports · 2021Article
- Nanoneedle-Based Materials for Intracellular Studies.Advances in experimental medicine and biology · 2021Article
- Emerging Roles of 1D Vertical Nanostructures in Orchestrating Immune Cell Functions.Advanced materials (Deerfield Beach, Fla.) · 2020Review
- High-Aspect-Ratio Nanostructured Surfaces as Biological Metamaterials.Advanced materials (Deerfield Beach, Fla.) · 2020Review
- A method using electroporation for the protein delivery of Cre recombinase into cultured Arabidopsis cells with an intact cell wall.Scientific reports · 2019Article
- Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts.Chemical reviews · 2018Review
- Talking to cells: semiconductor nanomaterials at the cellular interface.Advanced biosystems · 2018Article
- Analysis of poration-induced changes in cells from laser-activated plasmonic substrates.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delivery of biomolecules with use of nanostructures has been previously reported. However, both efficient and high-throughput intracellular delivery has proved difficult to achieve. Here, we report a novel material and device for the delivery of biomacromolecules into live cells. We attribute the successful results to the unique features of the system, which include high-aspect-ratio, uniform nanoneedles laid across a 2D array, combined with an oscillatory feature, which together allow rapid, forcible and efficient insertion and protein release into thousands of cells simultaneously.
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Registered trials
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