ArticleThe Journal of comparative neurology2016
The mesencephalic locomotor region sends a bilateral glutamatergic drive to hindbrain reticulospinal neurons in a tetrapod.
Article in The Journal of comparative neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Cell-type Plasticity Supports Behavioral Adaptations at the Water-to-Land Interface.bioRxiv : the preprint server for biology · 2026Article
- Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord.PLoS computational biology · 2025Article
- The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish.Nature neuroscience · 2023Article
- Granger causality analysis for calcium transients in neuronal networks, challenges and improvements.eLife · 2023Article
- Brainstem neural mechanisms controlling locomotion with special reference to basal vertebrates.Frontiers in neural circuits · 2023Review
- From retina to motoneurons: A substrate for visuomotor transformation in salamanders.The Journal of comparative neurology · 2022Article
- Cholinergic Modulation of Locomotor Circuits in Vertebrates.International journal of molecular sciences · 2022Review
- An early midbrain sensorimotor pathway is involved in the timely initiation and direction of swimming in the hatchlingFrontiers in neural circuits · 2022Article
- Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Freely Behaving Mice Can Brake and Turn During Optogenetic Stimulation of the Mesencephalic Locomotor Region.Frontiers in neural circuits · 2021Article
- Descending Dopaminergic Inputs to Reticulospinal Neurons Promote Locomotor Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HTJournal of neurophysiology · 2020Article
- Reproducing Five Motor Behaviors in a Salamander Robot With Virtual Muscles and a Distributed CPG Controller Regulated by Drive Signals and Proprioceptive Feedback.Frontiers in neurorobotics · 2020Article
- Serotonergic Modulation of Locomotor Activity From Basal Vertebrates to Mammals.Frontiers in neural circuits · 2020Review
- A Neuronal Pathway that Commands Deceleration in Drosophila Larval Light-Avoidance.Neuroscience bulletin · 2019Article
- Morphological and electrophysiological properties of serotonin neurons with NMDA modulation in the mesencephalic locomotor region of neonatal ePet-EYFP mice.Experimental brain research · 2019Article
- A Brainstem Neural Substrate for Stopping Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Parallel descending dopaminergic connectivity of A13 cells to the brainstem locomotor centers.Scientific reports · 2018Article
- Role of the pedunculopontine nucleus in controlling gait and sleep in normal and parkinsonian monkeys.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
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4 authors.
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Abstract
In vertebrates, stimulation of the mesencephalic locomotor region (MLR) on one side evokes symmetrical locomotor movements on both sides. How this occurs was previously examined in detail in a swimmer using body undulations (lamprey), but in tetrapods the downstream projections from the MLR to brainstem neurons are not fully understood. Here we examined the brainstem circuits from the MLR to identified reticulospinal neurons in the salamander Notophthalmus viridescens. Using neural tracing, we show that the MLR sends bilateral projections to the middle reticular nucleus (mRN, rostral hindbrain) and the inferior reticular nucleus (iRN, caudal hindbrain). Ca(2+) imaging coupled to electrophysiology in in vitro isolated brains revealed very similar responses in reticulospinal neurons on both sides to a unilateral MLR stimulation. As the strength of MLR stimulation was increased, the responses increased in size in reticulospinal neurons of the mRN and iRN, but the responses in the iRN were smaller. Bath-application or local microinjections of glutamatergic antagonists markedly reduced reticulospinal neuron responses, indicating that the MLR sends glutamatergic inputs to reticulospinal neurons. In addition, reticulospinal cells responded to glutamate microinjections and the size of the responses paralleled the amount of glutamate microinjected. Immunofluorescence coupled with anatomical tracing confirmed the presence of glutamatergic projections from the MLR to reticulospinal neurons. Overall, we show that the brainstem circuits activated by the MLR in the salamander are organized similarly to those previously described in lampreys, indicating that the anatomo-physiological features of the locomotor drive are well conserved in vertebrates. J. Comp. Neurol. 524:1361-1383, 2016. © 2015 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.
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