ArticlePloS one2015
Healthcare Associated Infections of Methicillin-Resistant Staphylococcus aureus: A Case-Control-Control Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Estimating the burden of antimicrobial resistance: a systematic literature review.Antimicrobial resistance and infection control · 2018Pooled it
- Clinical and economic impact of antibiotic resistance in developing countries: A systematic review and meta-analysis.PloS one · 2017Pooled it
- Pooled it
- MRSA-related knowledge, attitudes, and practices among clinical dental students: a cross-sectional study with implications for infection prevention and control education and training.Frontiers in oral health · 2026Article
- Human and Veterinary Medicine Collaboration: Synergistic Approach to Address Antimicrobial Resistance Through the Lens of Planetary Health.Antibiotics (Basel, Switzerland) · 2025Review
- Impact of Limiting Vancomycin Loading Doses in Patients With Methicillin-resistantHospital pharmacy · 2024Article
- Direct Quantitative Immunochemical Analysis of Autoinducer Peptide IV for Diagnosing and StratifyingACS infectious diseases · 2022Article
- Investigation on the biofilm eradication potential of selected medicinal plants against methicillin-resistantBiotechnology reports (Amsterdam, Netherlands) · 2020Article
- Vancomycin Use in a Paediatric Intensive Care Unit of a Tertiary Care Hospital.Paediatric drugs · 2019Article
- Methicillin-resistant Staphylococcus aureus nasal colonization and infection in an intensive care unit of a university hospital in China.The Journal of international medical research · 2018Article
- One-year and long-term mortality in patients hospitalized for chronic obstructive pulmonary disease.Journal of thoracic disease · 2017Article
- Drug-resistance dynamics of Staphylococcus aureus between 2008 and 2014 at a tertiary teaching hospital, Jiangxi Province, China.BMC infectious diseases · 2017Article
- Hospital-Acquired Methicillin-resistantHawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMethicillin-resistant Staphylococcus aureus (MRSA) is one of the most widespread and dangerous pathogens in healthcare settings. We carried out this case-control-control study at a tertiary care hospital in Guangzhou, China, to examine the antimicrobial susceptibility patterns, risk factors and clinical outcomes of MRSA infections.
methodsA total of 57 MRSA patients, 116 methicillin-susceptible Staphylococcus aureus (MSSA) patients and 102 S. aureus negative patients were included in this study. We applied the disk diffusion method to compare the antimicrobial susceptibilities of 18 antibiotics between MRSA and MSSA isolates. Risk factors of MRSA infections were evaluated using univariate and multivariate logistic regression models. We used Cox proportional hazards models and logistic regression analysis to assess the hospital stay duration and fatality for patients with MRSA infections.
resultsThe MRSA group had significantly higher resistance rates for most drugs tested compared with the MSSA group. Using MSSA patients as controls, the following independent risk factors of MRSA infections were identified: 3 or more prior hospitalizations (OR 2.8, 95% CI 1.3-5.8, P = 0.007), chronic obstructive pulmonary disease (OR 5.9, 95% CI 1.7-20.7, P = 0.006), and use of a respirator (OR 3.6, 95% CI 1.0-12.9, P = 0.046). With the S. aureus negative patients as controls, use of a respirator (OR 3.8, 95% CI 1.0-13.9, P = 0.047) and tracheal intubation (OR 8.2, 95% CI 1.5-45.1, P = 0.016) were significant risk factors for MRSA infections. MRSA patients had a longer hospital stay duration and higher fatality in comparison with those in the two control groups.
conclusionsMRSA infections substantially increase hospital stay duration and fatality. Thus, MRSA infections are serious issues in this healthcare setting and should receive more attention from clinicians.
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