ArticleTransfusion2015
In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome.
Article in Transfusion, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Prolonged red cell storage before transfusion increases extravascular hemolysis.The Journal of clinical investigation · 2017Trial
- Continuous blood exchange in rats as a novel approach for experimental investigation.Scientific reports · 2024Article
- Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Large Animal Models for Simulating Physiology of Transfusion of Red Cell Concentrates-A Scoping Review of The Literature.Medicina (Kaunas, Lithuania) · 2022Article
- Age of Red Cells for Transfusion and Outcomes in Patients with ARDS.Journal of clinical medicine · 2022Article
- Effect of washing units of canine red blood cells on storage lesions.Journal of veterinary internal medicine · 2022Article
- RBC Storage Lesion Studies in Humans and Experimental Models of Shock.Applied sciences (Basel, Switzerland) · 2020Article
- Diversity in a blood bag: application of omics technologies to inform precision Transfusion Medicine.Blood transfusion = Trasfusione del sangue · 2019Article
- Role of redox iron towards an increase in mortality among patients: a systemic review and meta-analysis.Blood research · 2019Review
- Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016.Transfusion · 2018Article
- Effect of red blood cell storage time on markers of hemolysis and inflammation in transfused very low birth weight infants.Pediatric research · 2017Observational
- The red cell storage lesion(s): of dogs and men.Blood transfusion = Trasfusione del sangue · 2017Review
- The controversy over the age of blood: what do the clinical trials really teach us?Blood transfusion = Trasfusione del sangue · 2017Review
- Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells.Circulation · 2016Article
- Could Microparticles Be the Universal Quality Indicator for Platelet Viability and Function?Journal of blood transfusion · 2016Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMassive exchange transfusion of 42-day-old red blood cells (RBCs) in a canine model of Staphylococcus aureus pneumonia resulted in in vivo hemolysis with increases in cell-free hemoglobin (CFH), transferrin-bound iron (TBI), non-transferrin-bound iron (NTBI), and mortality. We have previously shown that washing 42-day-old RBCs before transfusion significantly decreased NTBI levels and mortality, but washing 7-day-old RBCs increased mortality and CFH levels. We now report the results of altering volume, washing, and age of RBCs. STUDY DESIGN AND
methodsTwo-year-old purpose-bred infected beagles were transfused with increasing volumes (5-10, 20-40, or 60-80 mL/kg) of either 42- or 7-day-old RBCs (n = 36) or 80 mL/kg of either unwashed or washed RBCs with increasing storage age (14, 21, 28, or 35 days; n = 40).
resultsAll volumes transfused (5-80 mL/kg) of 42-day-old RBCs resulted in alike (i.e., not significantly different) increases in TBI during transfusion as well as in CFH, lung injury, and mortality rates after transfusion. Transfusion of 80 mL/kg RBCs stored for 14, 21, 28, and 35 days resulted in increased CFH and NTBI in between levels found at 7 and 42 days of storage. However, washing RBCs of intermediate ages (14-35 days) does not alter NTBI and CFH levels or mortality rates.
conclusionsPreclinical data suggest that any volume of 42-day-old blood potentially increases risks during established infection. In contrast, even massive volumes of 7-day-old blood result in minimal CFH and NTBI levels and risks. In contrast to the extremes of storage, washing blood stored for intermediate ages does not alter risks of transfusion or NTBI and CFH clearance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.