ArticleScientific reports2015
Dysfunctional Default Mode Network in Methadone Treated Patients Who Have a Higher Heroin Relapse Risk.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Can neuroimaging help combat the opioid epidemic? A systematic review of clinical and pharmacological challenge fMRI studies with recommendations for future research.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Pooled it
- Longitudinal brain dynamics and prediction of craving changes in individuals with methamphetamine use disorder.Translational psychiatry · 2026Article
- Cognition-Eye-Brain Connection in Alzheimer's Disease Spectrum Revealed by Multimodal Imaging.Journal of magnetic resonance imaging : JMRI · 2025Article
- Functional brain network identification in opioid use disorder using machine learning analysis of resting-state fMRI BOLD signals.Computers in biology and medicine · 2025Article
- Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder.JAMA network open · 2025Article
- Resting State Functional Connectivity of the Default Mode Network During Opioid Use and Cessation in Treatment-Seeking Persons.The European journal of neuroscience · 2025Article
- Neuroimaging of opioid effects in humans across conditions of acute administration, chronic pain therapy, and opioid use disorder.Trends in neurosciences · 2024Review
- Glymphatic-System Function Is Associated with Addiction and Relapse in Heroin Dependents Undergoing Methadone Maintenance Treatment.Brain sciences · 2023Article
- Impact of binge drinking during college on resting state functional connectivity.Drug and alcohol dependence · 2021Article
- Article
- Temporal Dynamics of Large-Scale Networks Predict Neural Cue Reactivity and Cue-Induced Craving.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- The role of catecholamines in modulating responses to stress: Sex-specific patterns, implications, and therapeutic potential for post-traumatic stress disorder and opiate withdrawal.The European journal of neuroscience · 2020Review
- Proposing FDA consideration for the treatment and prophylaxis of opioid and psychostimulant abuse to incorporate the induction of DNA guided dopamine homeostasis: Anti-reward deficiency restoration solution (ARDS).Journal of systems and integrative neuroscience · 2020Article
- Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy.Neuroscience bulletin · 2019Article
- Alterations in resting-state functional connectivity in substance use disorders and treatment implications.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Current understanding of the neurobiology of opioid use disorder: An overview.Current behavioral neuroscience reports · 2019Article
- Functional Correlates of Resting-State Connectivity in the Default Mode Network of Heroin Users on Methadone Treatment and Medication-Free Therapeutic Community Program.Frontiers in psychiatry · 2019Article
- Bouncing back: Brain rehabilitation amid opioid and stimulant epidemics.NeuroImage. Clinical · 2019Review
- Disrupted coupling of large-scale networks is associated with relapse behaviour in heroin-dependent men.Journal of psychiatry & neuroscience : JPN · 2018Article
- Fifty Years in the Development of a Glutaminergic-Dopaminergic Optimization Complex (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome: A Pictorial.Austin addiction sciences · 2016Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to identify whether heroin relapse is associated with changes in the functional connectivity of the default mode network (DMN) during methadone maintenance treatment (MMT). Resting-state functional magnetic resonance imaging (fMRI) data of chronic heroin relapsers (HR) (12 males, 1 female, age: 36.1 ± 6.9 years) and abstainers (HA) (11males, 2 female; age: 42.1 ± 8.1 years) were investigated with an independent component analysis to address the functional connectivity of their DMN. Group comparison was then performed between the relapsers and abstainers. Our study found that the left inferior temporal gyrus and the right superior occipital gyrus associated with DMN showed decreased functional connectivity in HR when compared with HA, while the left precuneus and the right middle cingulum had increased functional connectivity. Mean intensity signal, extracted from left inferior temporal gyrus of HR patients, showed a significant negative correlation corresponding to the degree of heroin relapse. These findings suggest that altered functional connectivity of DMN may contribute to the potential neurobiological mechanism(s) of heroin relapse and have a predictive value concerning heroin relapse under MMT.
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