ArticleJournal of neuroscience research2016
Childhood Cumulative Risk Exposure and Adult Amygdala Volume and Function.
Article in Journal of neuroscience research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
43 citing papers in PubMed, 75 citations in OpenAlex.
- Neural function during emotion processing and modulation associated with treatment response in a randomized clinical trial for posttraumatic stress disorder.Depression and anxiety · 2020Trial
- Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRHbioRxiv : the preprint server for biology · 2026Article
- Imaging biomarkers in functional neurological disorders.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Adversity as the key feature: neuroimaging profiles of subtypes from multiple depression risk factors.Psychological medicine · 2026Article
- Parenting behaviors over time and their effects on cortical and limbic brain structure in children and young adults.Developmental cognitive neuroscience · 2026Article
- Pre-trauma hair cortisol moderates adverse childhood experience and hypothalamic volume effects on stress symptoms after adult trauma.Translational psychiatry · 2026Article
- Functional Neurologic Disorder,Neurology · 2024Article
- The brain, gut, and bladder health nexus: A conceptual model linking stress and mental health disorders to overactive bladder in women.Neurourology and urodynamics · 2024Article
- A global multicohort study to map subcortical brain development and cognition in infancy and early childhood.Nature neuroscience · 2024Article
- Adverse childhood experiences, brain function, and psychiatric diagnoses in a large adult clinical cohort.Frontiers in psychiatry · 2024Article
- Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.Science advances · 2023Article
- Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma.Translational psychiatry · 2023Article
- Neighborhood Social Determinants of Health in Patients Seen in Neurology Movement Disorders Clinics.Neurology. Clinical practice · 2023Article
- Association of age of adverse childhood experiences with thalamic volumes and post-traumatic stress disorder in adulthood.Frontiers in behavioral neuroscience · 2023Article
- Article
- Disrupted development from head to tail: Pervasive effects of postnatal restricted resources on neurobiological, behavioral, and morphometric outcomes.Frontiers in behavioral neuroscience · 2022Article
- Adverse childhood experiences associate with early post-trauma thalamus and thalamic nuclei volumes and PTSD development in adulthood.Psychiatry research. Neuroimaging · 2022Article
- Neurocircuitry of Contingency Awareness in Pavlovian Fear Conditioning.Cognitive, affective & behavioral neuroscience · 2021Article
- Migration-related trauma and mental health among migrant children emigrating from Mexico and Central America to the United States: Effects on developmental neurobiology and implications for policy.Developmental psychobiology · 2021Review
- Ecological stress, amygdala reactivity, and internalizing symptoms in preadolescence: Is parenting a buffer?Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
Considerable work indicates that early cumulative risk exposure is aversive to human development, but very little research has examined the neurological underpinnings of these robust findings. This study investigates amygdala volume and reactivity to facial stimuli among adults (mean 23.7 years of age, n = 54) as a function of cumulative risk exposure during childhood (9 and 13 years of age). In addition, we test to determine whether expected cumulative risk elevations in amygdala volume would mediate functional reactivity of the amygdala during socioemotional processing. Risks included substandard housing quality, noise, crowding, family turmoil, child separation from family, and violence. Total and left hemisphere adult amygdala volumes were positively related to cumulative risk exposure during childhood. The links between childhood cumulative risk exposure and elevated amygdala responses to emotionally neutral facial stimuli in adulthood were mediated by the corresponding amygdala volumes. Cumulative risk exposure in later adolescence (17 years of age), however, was unrelated to subsequent adult amygdala volume or function. Physical and socioemotional risk exposures early in life appear to alter amygdala development, rendering adults more reactive to ambiguous stimuli such as neutral faces. These stress-related differences in childhood amygdala development might contribute to the well-documented psychological distress as a function of early risk exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.