Evidence map›Paper›PMID 26469833›Full record

ArticleBritish journal of cancer2015

P4H9-detected molecule expression on spindle-shaped fibroblasts indicates malignant phenotype of colorectal cancer.

Shozo Yokoyama, Junji Ieda, Naoyuki Yamamoto, Shunsuke Yamaguchi, Yasuyuki Mitani, Akihiro Takeuchi, Katsunari Takifuji, Tsukasa Hotta, Kenji Matsuda, Takashi Watanabe and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shozo YokoyamaSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.
Junji IedaSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.
Naoyuki YamamotoSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.
Shunsuke YamaguchiSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.
Yasuyuki MitaniSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.
Akihiro TakeuchiSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.
Katsunari TakifujiSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.
Tsukasa HottaSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.
Kenji MatsudaSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.
Takashi WatanabeSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.
John E ShivelyDepartment of Immunology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Hiroki YamaueSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama 641-8510, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOur previous study using a mammary fat pad mouse model showed that P4H9, produced by the β2 integrin epitope, detected a molecule on fibroblasts in response to carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)-expressing cancer cells. P4H9-detected molecule (PDM) expression appeared to be associated with myofibroblast differentiation. In this study, we investigated whether PDM is expressed on fibroblasts and cancer cells in clinical tissue samples, and whether the presence of PDM-expressing colorectal cancer cells is correlated with clinicopathological features of patients.

methodsImmunohistochemistry was conducted to detect P4H9 on clinical tissue samples from 156 patients with colorectal cancer. Risk factors for metastases and survival were calculated for clinical implication of PDM-expressing spindle-shaped fibroblasts.

resultsMultivariate analysis showed that PDM-expressing spindle-shaped fibroblasts were an independent risk factor for lymph node metastasis, hematogenous metastasis, and poor survival. A Kaplan-Meier survival curve indicated that PDM-expressing spindle-shaped fibroblasts were associated with shorter survival time (P<0.0001). Immunofluorescence showed PDM expression on CCD-18Co fibroblasts and two colorectal cancer cell lines (HCT116 and HCT-15).

conclusionsPDM-expressing spindle-shaped fibroblasts are associated with metastasis and shorter survival in colorectal cancer patients. PDM-expressing spindle-shaped fibroblasts may have a role in eliciting the malignant phenotype of colorectal cancer.

Indexed as

Antigens, CDCD18 AntigensCell Adhesion MoleculesColorectal NeoplasmsEpitopesFemaleFibroblastsHCT116 CellsHT29 CellsHumansMaleMiddle AgedMultivariate AnalysisNeoplasm MetastasisPrognosisSurvival AnalysisAntigens, CDCD18 AntigensCD66 antigensCell Adhesion MoleculesEpitopes

Identifiers

PMID26469833
PMCPMC4815886

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.