ArticlePloS one2015
Differential Predictive Roles of A- and B-Type Nuclear Lamins in Prostate Cancer Progression.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- Lamin A/C as a Molecular Link Between Nuclear Organization, Chromatin Dynamics, and Tumor Progression.Cells · 2026Review
- Variable A-type lamin expression in Merkel cell carcinoma cell lines and its association with nuclear integrity.Scientific reports · 2026Article
- Advances in research on the relationship between the LMNA gene and human diseases (Review).Molecular medicine reports · 2024Review
- Altered expression and localization of nuclear envelope proteins in a prostate cancer cell system.Molecular biology reports · 2024Article
- Mechanism and role of nuclear laminin B1 in cell senescence and malignant tumors.Cell death discovery · 2024Review
- Knockdown ofCell adhesion & migration · 2023Article
- LMNB1, a potential marker for early prostate cancer progression.American journal of cancer research · 2022Article
- Article
- Long Noncoding RNAFrontiers in oncology · 2021Article
- Lamin A/C: Function in Normal and Tumor Cells.Cancers · 2020Review
- Identification of metastatic cell nucleus in human prostate cancer by electron microscopy.Future science OA · 2020Article
- miR-122 Inhibits Hepatocarcinoma Cell Progression by Targeting LMNB2.Oncology research · 2020Article
- Tailoring Cellular Function: The Contribution of the Nucleus in Mechanotransduction.Frontiers in bioengineering and biotechnology · 2020Review
- Assessment of the Utility of Gene Positioning Biomarkers in the Stratification of Prostate Cancers.Frontiers in genetics · 2019Article
- Advances in the computational and molecular understanding of the prostate cancer cell nucleus.Journal of cellular biochemistry · 2018Review
- Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?Cells · 2018Review
- Mechanotransduction in tumor progression: The dark side of the force.The Journal of cell biology · 2018Review
- Lamin B2 binding to minichromosome maintenance complex component 7 promotes non-small cell lung carcinogenesis.Oncotarget · 2017Article
- Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus.Molecular biology of the cell · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProstate cancer (PCa) is the most common cancer among men in western countries. While active surveillance is increasingly utilized, the majority of patients are currently treated with radical prostatectomy. In order to avoid over-treatment, there is an indisputable need for reliable biomarkers to identify the potentially aggressive and lethal cases. Nuclear intermediate filament proteins called lamins play a role in chromatin organization, gene expression and cell stiffness. The expression of lamin A is associated with poor outcome in colorectal cancer but to date the prognostic value of the lamins has not been tested in other solid tumors.
methodsWe studied the expression of different lamins with immunohistochemistry in a tissue microarray material of 501 PCa patients undergoing radical prostatectomy and lymph node dissection. Patients were divided into two staining categories (low and high expression). The correlation of lamin expression with clinicopathological variables was tested and the association of lamin status with biochemical recurrence (BCR) and disease specific survival (DSS) was further analyzed.
resultsLow expression of lamin A associated with lymph node positivity (p<0.01) but not with other clinicopathological variables and low expression had a borderline independent significant association with DSS (HR = 0.4; 95% CI 0.2-1.0; p = 0.052). Similarly, low lamin C expression associated with poorer survival (HR = 0.2; 95% CI 0.1-0.6; p = 0.004). Lamin B1 expression did not associate with clinicopathological variables but high expression independently predicted BCR in multivariable Cox regression analysis (HR = 1.8; 95% CI 1.1-2.9; p = 0.023). Low expression of lamin B2 correlated with lymph node positivity (p<0.01) and predicted unfavorable DSS (HR = 0.4; 95% CI 0.2-1.0; p = 0.047).
conclusionsThese results suggest differential roles for lamins in PCa progression. Reduced amounts of lamin A/C and B2 increase risk for lymph node metastasis and disease specific death possibly through increased nuclear deformability while high expression of lamin B1 predicts disease recurrence.
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