ArticleOptics letters2015
Direct four-dimensional structural and functional imaging of cardiovascular dynamics in mouse embryos with 1.5 MHz optical coherence tomography.
Article in Optics letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Automated processing pipeline for functional imaging of human cardiac organoids using optical coherence tomography.Biomedical optics express · 2026Article
- Open-source, highly efficient, post-acquisition synchronization for 4D dual-contrast imaging of the mouse embryonic heart over development with optical coherence tomography.Biomedical optics express · 2023Article
- Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart.Journal of cardiovascular development and disease · 2022Review
- Fourier Domain Mode Locked Laser and Its Applications.Sensors (Basel, Switzerland) · 2022Review
- Mouse embryo phenotyping with optical coherence tomography.Frontiers in cell and developmental biology · 2022Review
- Multimodal high-resolution embryonic imaging with light sheet fluorescence microscopy and optical coherence tomography.Optics letters · 2021Article
- In vivo dynamic 3D imaging of oocytes and embryos in the mouse oviduct.Cell reports · 2021Article
- Compressional Optical Coherence Elastography of the Cornea.Photonics · 2021Article
- Embryonic Mouse Cardiodynamic OCT Imaging.Journal of cardiovascular development and disease · 2020Review
- Live mechanistic assessment of localized cardiac pumping in mammalian tubular embryonic heart.Journal of biomedical optics · 2020Article
- 9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking.Scientific reports · 2020Article
- Label-free optical imaging in developmental biology [Invited].Biomedical optics express · 2020Review
- Tissue biomechanics during cranial neural tube closure measured by Brillouin microscopy and optical coherence tomography.Birth defects research · 2019Article
- Staging mouse preimplantation development in vivo using optical coherence microscopy.Journal of biophotonics · 2019Article
- Article
- Prolonged in vivo functional assessment of the mouse oviduct using optical coherence tomography through a dorsal imaging window.Journal of biophotonics · 2018Article
- Evaluating the effects of maternal alcohol consumption on murine fetal brain vasculature using optical coherence tomography.Journal of biophotonics · 2018Article
- Complex regression Doppler optical coherence tomography.Journal of biomedical optics · 2018Article
- Article
- Flexible wide-field optical micro-angiography based on Fourier-domain multiplexed dual-beam swept source optical coherence tomography.Journal of biophotonics · 2018Article
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Authors and funding
9 authors.
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Abstract
High-resolution three-dimensional (3D) imaging of cardiovascular dynamics in mouse embryos is greatly desired to study mammalian congenital cardiac defects. Here, we demonstrate direct four-dimensional (4D) imaging of the cardiovascular structure and function in live mouse embryos at a ∼43 Hz volume rate using an optical coherence tomography (OCT) system with a ∼1.5 MHz Fourier domain mode-locking swept laser source. Combining ultrafast OCT imaging with live mouse embryo culture protocols, 3D volumes of the embryo are directly and continuously acquired over time for a cardiodynamics analysis without the application of any synchronization algorithms. We present the time-resolved measurements of the heart wall motion based on the 4D structural data, report 4D speckle variance and Doppler imaging of the vascular system, and quantify spatially resolved blood flow velocity over time. These results indicate that the ultra-high-speed 4D imaging approach could be a useful tool for efficient cardiovascular phenotyping of mouse embryos.
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