SynthesisPain2015
Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations.
Synthesis in Pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of Genetic Variant at Chromosome 12q23.1 With Neuropathic Pain Susceptibility.JAMA network open · 2021Pooled it
- Physiological Measures of Acute and Chronic Pain within Different Subject Groups: A Systematic Review.Pain research & management · 2020Pooled it
- Optimal clinical assessment strategies for chemotherapy-induced peripheral neuropathy (CIPN): a systematic review and Delphi survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Pooled it
- Symptom-driven co-existence of diabetic autonomic neuropathy, peripheral neuropathy, and painful neuropathy.Acta diabetologica · 2026Article
- Phenotyping Chronic Pain and Neuropathic Pain in Population Studies.European journal of pain (London, England) · 2025Review
- A Workload Indicators of Staffing Need (WISN) based framework and implementation tool for dietitians at South African central and tertiary public hospitals.BMC health services research · 2025Article
- Tonic excitation by astrocytic GABA causes neuropathic pain by augmenting neuronal activity and glucose metabolism.Experimental & molecular medicine · 2024Article
- A Systematic Scoping Review of Essential Methodological Elements for Developing a Tool to Improve the Reporting of Consensus Studies in Classification, Diagnostic Criteria, and Guidelines Development.Journal of multidisciplinary healthcare · 2024Article
- The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury.Journal of orthopaedic surgery and research · 2023Article
- Big data, big consortia, and pain: UK Biobank, PAINSTORM, and DOLORisk.Pain reports · 2023Article
- Implementation of Precision Oncology in the National Healthcare System: A Statement Proposal Endorsed by Italian Scientific Societies.JCO precision oncology · 2023Article
- Epidemiology of neuropathic pain: an analysis of prevalence and associated factors in UK Biobank.Pain reports · 2023Article
- Symptom descriptors and patterns in lumbar radicular pain caused by disc herniation: a 1-year longitudinal cohort study.BMJ open · 2022Article
- VAS and NRS, Same or Different? Are Visual Analog Scale Values and Numerical Rating Scale Equally Viable Tools for Assessing Patients after Microdiscectomy?Pain research & management · 2022Article
- Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development.Journal of experimental & clinical cancer research : CR · 2021Review
- Corneal Nerve Abnormalities in Painful Dry Eye Disease Patients.Biomedicines · 2021Article
- Article
- Digital Pain Mapping and Tracking in Patients With Chronic Pain: Longitudinal Study.Journal of medical Internet research · 2020Article
- Article
- Guideline "diagnosis and non interventional therapy of neuropathic pain" of the German Society of Neurology (deutsche Gesellschaft für Neurologie).Neurological research and practice · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors.
Funding
Abstract
For genetic research to contribute more fully to furthering our knowledge of neuropathic pain, we require an agreed, valid, and feasible approach to phenotyping, to allow collaboration and replication in samples of sufficient size. Results from genetic studies on neuropathic pain have been inconsistent and have met with replication difficulties, in part because of differences in phenotypes used for case ascertainment. Because there is no consensus on the nature of these phenotypes, nor on the methods of collecting them, this study aimed to provide guidelines on collecting and reporting phenotypes in cases and controls for genetic studies. Consensus was achieved through a staged approach: (1) systematic literature review to identify all neuropathic pain phenotypes used in previous genetic studies; (2) Delphi survey to identify the most useful neuropathic pain phenotypes and their validity and feasibility; and (3) meeting of experts to reach consensus on the optimal phenotype(s) to be collected from patients with neuropathic pain for genetic studies. A basic "entry level" set of phenotypes was identified for any genetic study of neuropathic pain. This set identifies cases of "possible" neuropathic pain, and controls, and includes: (1) a validated symptom-based questionnaire to determine whether any pain is likely to be neuropathic; (2) body chart or checklist to identify whether the area of pain distribution is neuroanatomically logical; and (3) details of pain history (intensity, duration, any formal diagnosis). This NeuroPPIC "entry level" set of phenotypes can be expanded by more extensive and specific measures, as determined by scientific requirements and resource availability.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.