ArticleJournal of neuropathology and experimental neurology2015
Neuropsychological Markers of Cognitive Decline in Persons With Alzheimer Disease Neuropathology.
Article in Journal of neuropathology and experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Detectable Neuropsychological Differences in Early Preclinical Alzheimer's Disease: A Meta-Analysis.Neuropsychology review · 2017Pooled it
- Metabolic Regulatory Networks in Ferroptosis During Alzheimer's Disease, Mechanisms of Glial Cell Action, and Pathological Correlations with Neuritic Plaques.International journal of general medicine · 2026Review
- Longitudinal assessment of cognitive decline and resilience in high-level Alzheimer disease neuropathologic change.Alzheimer's research & therapy · 2025Article
- Cognitive and neuropsychological trajectories in patients with mixed neurodegenerative pathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Baseline and longitudinal changes in cortical thickness and hippocampal volume predict cognitive decline.Journal of Alzheimer's disease : JAD · 2025Article
- Unraveling the clinical-pathological correlations of subjects with isolated and mixed neurodegenerative processes in the National Alzheimer's Coordinating Center dataset.Journal of neuropathology and experimental neurology · 2025Article
- Pick a PACC: Comparing domain-specific and general cognitive composites in Alzheimer disease research.Neuropsychology · 2024Article
- Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies.Acta neuropathologica · 2024Article
- Single-value scores of memory-related brain activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging.Human brain mapping · 2023Article
- A microRNA signature that correlates with cognition and is a target against cognitive decline.EMBO molecular medicine · 2021Article
- Is comprehensiveness critical? Comparing short and long format cognitive assessments in preclinical Alzheimer disease.Alzheimer's research & therapy · 2021Article
- The Free and Cued Selective Reminding Test Predicts Braak Stage.Journal of Alzheimer's disease : JAD · 2021Article
- Stages of Objective Memory Impairment Predict Alzheimer's Disease Neuropathology: Comparison with the Clinical Dementia Rating Scale-Sum of Boxes.Journal of Alzheimer's disease : JAD · 2021Article
- Feasibility of Repeated Assessment of Cognitive Function in Older Adults Using a Wireless, Mobile, Dry-EEG Headset and Tablet-Based Games.Frontiers in psychiatry · 2021Article
- Association of Neighborhood-Level Disadvantage With Alzheimer Disease Neuropathology.JAMA network open · 2020Article
- Development and validation of language and visuospatial composite scores in ADNI.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Cognitive composite score association with Alzheimer's disease plaque and tangle pathology.Alzheimer's research & therapy · 2018Article
- Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study.JAMA neurology · 2016Article
- Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly.Journal of Alzheimer's disease : JAD · 2016Article
- Chocolate, Air Pollution and Children's Neuroprotection: What Cognition Tools should be at Hand to Evaluate Interventions?Frontiers in pharmacology · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
To evaluate cognitive performance among persons who did and did not develop clinical Alzheimer disease (AD) but had AD neuropathology at autopsy, we examined neuropsychological performance in cognitively healthy (Clinical Dementia Rating [CDR] = 0) participants who returned for at least 1 follow-up and died within 2 years of their last assessment. Nonprogressors remained at CDR = 0 until death; progressors developed symptomatic AD during life (CDR > 0). Cognitive performance at baseline was compared between progressors and nonprogressors on a global cognitive composite and 4 domain-specific composites (episodic memory, language, attention/working memory, and executive function). Models adjusted for age, education, sex, and non-AD neuropathology. Progressors (n = 173) had worse performance than nonprogressors (n = 141) in nearly all cognitive domains. Progressors scored lower on composites of global cognition (P < 0.001), executive function (P = 0.0006), language (P < 0.0001), and episodic memory (P = 0.0006) but not on attention/working memory (P = 0.91). These data indicate that individuals with underlying AD neuropathology who are clinically healthy but who later develop symptomatic AD have worse performance in a wide range of domains versus individuals with underlying AD neuropathology who are clinically healthy but do not become symptomatic during life. Therefore, subtle cognitive decline at baseline may indicate an increased risk of progression to symptomatic AD.
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