ArticleJournal of child and adolescent psychopharmacology2015
Evaluation of the Safety of Quetiapine in Treating Delirium in Critically Ill Children: A Retrospective Review.
Article in Journal of child and adolescent psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03572257 (Prospective, Double-Blind, Randomized Controlled Trial of Quetiapine as a Treatment for Delirium in Critically Ill Children), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective, Double-Blind, Randomized Controlled Trial of Quetiapine as a Treatment for Delirium in Critically Ill Children
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Antipsychotic Medications for Delirium Treatment in the Pediatric Intensive Care Unit: A Systematic Review.Paediatric drugs · 2025Pooled it
- State of the science in pediatric ICU delirium: An integrative review.Research in nursing & health · 2020Pooled it
- The Challenges of Diagnosing, Managing, and Preventing Pediatric Delirium.Children (Basel, Switzerland) · 2025Review
- A Family-Centred Paediatric Delirium Bundle: A Feasibility Study.Nursing in critical care · 2025Article
- Impact of Benzodiazepines on Outcomes of Mechanically Ventilated Pediatric Intensive Care Patients: A Retrospective Cohort Study.Critical care explorations · 2025Article
- Quetiapine and Paediatric Psychiatrica:Psychopharmacology bulletin · 2025Review
- Refractory agitation in the NICU: challenges in prevention, diagnosis, and treatment.Frontiers in pediatrics · 2025Article
- Current Evidence Regarding the Evaluation and Management of Neonatal Delirium.Current psychiatry reports · 2024Review
- Short-Term Effect of Quetiapine Used to Treat Delirium Symptoms on Opioid and Benzodiazepine Requirements in the Pediatric Cardiac Intensive Care Unit.Pediatric cardiology · 2024Article
- Antipsychotic Drug Prescription in Pediatric Intensive Care Units: A 10-Year U.S. Retrospective Database Study.Journal of pediatric intensive care · 2024Article
- Delirium in the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Differences in Delirium Evaluation and Pharmacologic Management in Children With Developmental Delay: A Retrospective Case-Control Study.Journal of intensive care medicine · 2024Article
- Assessment and Management of Delirium in the Pediatric Intensive Care Unit: A Review.Journal of pediatric intensive care · 2023Review
- Effects of a Multidisciplinary Stewardship Program on the Prevention of Delirium in the Pediatric Intensive Care Unit.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Severe irritability in a critically ill preterm infant: a case of delirium at the neonatal intensive care unit.Dementia & neuropsychologia · 2023Article
- Delirium Assessment Treatment Strategies in Critically Ill Pediatric Patients: A Pediatric Pharmacy Association Practice-Based Research Network Survey Study.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Recommendations for analgesia and sedation in critically ill children admitted to intensive care unit.Journal of anesthesia, analgesia and critical care · 2022Review
- Modified ABCDEF-Bundles for Critically Ill Pediatric Patients - What Could They Look Like?Frontiers in pediatrics · 2022Review
- Chlorpromazine as Treatment for Refractory Agitation Associated with Pediatric Delirium.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Implementation of a Delirium Bundle for Pediatric Intensive Care Patients.Frontiers in pediatrics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveQuetiapine is an atypical antipsychotic that has been used off-label for the treatment of intensive care unit (ICU) delirium in the adult population, with studies demonstrating both efficacy and a favorable safety profile. Although there is a potential role for quetiapine in the treatment of pediatric ICU delirium, there has been no systematic reporting to date of safety in this patient population.
methodsPharmacy records were used to identify 55 consecutive pediatric ICU patients who were diagnosed with delirium and received quetiapine. A comprehensive retrospective medical chart review was performed to collect data on demographics, dosing, and side effects.
resultsFifty patients treated between January 2013 and November 2014 were included, and five patients were excluded from the study. Subjects ranged in age from 2 months to 20 years. Median daily dose was 1.3 mg/kg/day, and median duration of treatment was 12 days. There were three episodes of QTc prolongation that were clinically nonsignificant with no associated dysrhythmia: Two resolved over time without intervention, and one resolved with decrease in quetiapine dosage. There were no episodes of extrapyramidal symptoms or neuroleptic malignant syndrome.
conclusionsIn this population of critically ill youth, short-term use of quetiapine as treatment for delirium appears to be safe, without serious adverse events. Further research is required to assess efficacy and evaluate for long-term effects. A prospective, randomized, placebo-controlled study of quetiapine in managing pediatric delirium is necessary.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.