ArticlePloS one2015
Changes in HIV Outcomes Following Depression Care in a Resource-Limited Setting: Results from a Pilot Study in Bamenda, Cameroon.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Systematic Review of Interventions for Depression for People Living with HIV in Africa.AIDS and behavior · 2018Pooled it
- Guideline
- Depression management and antiretroviral treatment outcome among people living with HIV in Northwest and East regions of Cameroon.BMC infectious diseases · 2022Trial
- Trial
- Integrating depression management into HIV primary care in central Malawi: the implementation of a pilot capacity building program.BMC health services research · 2018Trial
- Strategies to integrate non-communicable disease interventions in HIV and tuberculosis care contexts in low- and middle-income countries: a scoping review.BMJ global health · 2026Article
- A global scoping review of task shifting and sharing interventions to improve the mental health of people living with HIV/AIDS.Global mental health (Cambridge, England) · 2025Review
- Interventions Integrating Mental Health Services Into HIV Care in Africa; a Scoping Review.International journal of public health · 2025Article
- Early Outcomes of Mental Health Screening Integrated Into Routine HIV Care in Malawi.Global health, science and practice · 2024Article
- Prevalence and correlates of common mental disorders in people living with HIV in primary health care facilities in Ekurhuleni district.African journal of primary health care & family medicine · 2024Article
- Prevalence, risk factors and management of common mental health disorders in Cameroon: a systematic review.BMJ public health · 2024Article
- Factors influencing integration of mental health screening and treatment at HIV clinic settings in Cameroon: a qualitative study of health providers' perspectives.BMC health services research · 2024Article
- Gendered Racial Microaggressions, Self-silencing, Substance Use, and HIV Outcomes Among Black Women Living with HIV: A Structural Equation Modeling Approach.AIDS and behavior · 2024Article
- HIV-associated neurocognitive disorder: key implications of the microbiota-gut-brain axis.Frontiers in microbiology · 2024Review
- Effect of a brief psychological intervention for common mental disorders on HIV viral suppression: A non-randomised controlled study of the Friendship Bench in Zimbabwe.PLOS global public health · 2024Article
- Prevalence, severity, and associated factors of depression in newly diagnosed people living with HIV in Kilimanjaro, Tanzania: a cross-sectional study.BMC psychiatry · 2023Article
- The acceptability of antidepressant treatment in people living with HIV in Malawi: A patient perspective.Global public health · 2023Article
- Ethnic inequalities in mental health and socioeconomic status among older women living with HIV: results from the PRIME Study.Sexually transmitted infections · 2022Observational
- A Mixed-Methods Process Evaluation: Integrating Depression Treatment Into HIV Care in Malawi.Global health, science and practice · 2021Article
- Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about how improved depression care affects HIV-related outcomes in Africa. In a sample of depressed HIV patients in a low income, sub-Saharan country, we explored how implementing measurement-based antidepressant care (MBC) affected HIV outcomes over 4 months of antidepressant treatment.
methodsAs part of a project adapting MBC for use in Cameroon, we enrolled 41 depressed HIV patients on antiretroviral therapy in a pilot study in which a depression care manager (DCM) provided an outpatient HIV clinician with evidence-based decision support for antidepressant treatment. Acute depression management was provided for the first 12 weeks, with DCM contact every 2 weeks and HIV clinician appointments every 4 weeks. We measured HIV clinical and psychiatric outcomes at 4 months.
resultsParticipants were moderately depressed at baseline (mean Patient Health Questionnaire [PHQ] score = 14.4, range 13.1, 15.6). All HIV clinical outcomes improved by four month follow-up: mean (range) CD4 count improved from 436 (2, 860) to 452 (132, 876), mean (range) log-viral load decreased from 4.02 (3.86, 4.17) to 3.15 (2.81, 3.49), the proportion with virologic suppression improved from 0% to 18%, mean (range) HIV symptoms decreased from 6.4 (5.5, 7.3) to 3.1 (2.5, 3.7), the proportion reporting good or excellent health improved from 18% to 70%, and the proportion reporting any missed ARV doses in the past month decreased from 73% to 55%. Concurrently, psychiatric measures improved. The mean (range) PHQ score decreased from 14.4 (13.1, 15.6) to 1.6 (0.8, 2.4) and 90% achieved depression remission, while mean maladaptive coping style scores decreased and mean adaptive coping scores and self-efficacy scores improved.
conclusionIn this pilot study of an evidence-based depression treatment intervention for HIV-infected patients in Cameroon, a number of HIV behavioral and non-behavioral health outcomes improved over 4 months of effective depression treatment. These data are consistent with the hypothesis that better depression care can lead to improved HIV outcomes.
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