ArticlePloS one2015
Risk of Second Primary Cancer among Prostate Cancer Patients in Korea: A Population-Based Cohort Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prostate radiotherapy and the risk of secondary rectal cancer-a meta-analysis.International journal of colorectal disease · 2022Pooled it
- Risk of secondary rectal cancer and colon cancer after radiotherapy for prostate cancer: a meta-analysis.International journal of colorectal disease · 2018Pooled it
- Temporal trends in the risk of developing multiple primary cancers: a systematic review.BMC cancer · 2016Pooled it
- Effects of Radiation Therapy on the Incidence of Bladder Cancer and Rectal Cancer in Patients with Prostate Cancer: A Nationwide Nested Case-Control Study in Korean Population.The world journal of men's health · 2026Article
- Risk of second primary cancer after radiotherapy for localized prostate cancer: A single-center Korean cohort study.Investigative and clinical urology · 2026Article
- Rectal cancer following radiotherapy for prostate cancer: A propensity-matched analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Risk of second primary malignancies in prostate cancer patients: A Surveillance, Epidemiology, and End Results population-based study.Asian journal of urology · 2026Article
- Article
- Second primary cancers among males with a first primary prostate cancer: a population-based study in Northern Portugal.Clinical and experimental medicine · 2025Article
- Causal relationship between prostate cancer and 12 types of cancers: multivariable and bidirectional Mendelian randomization analyses.International urology and nephrology · 2024Article
- Review
- Cell Phone Radiation Exposure Limits and Engineering Solutions.International journal of environmental research and public health · 2023Review
- The Impact of a History of Different Other Cancers on the Long-Term Outcomes of Patients with Intrahepatic Cholangiocarcinoma: A Population-Based Analysis.BioMed research international · 2022Article
- Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the body.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Clinical characteristics and overall survival nomogram of second primary malignancies after prostate cancer, a SEER population-based study.Scientific reports · 2021Article
- Second Primary Malignancies in Patients With Hepatocellular Carcinoma: A Population-Based Analysis.Frontiers in oncology · 2021Article
- Does radiotherapy increase the risk of colorectal cancer among prostate cancer patients? A large population-based study.Journal of Cancer · 2020Article
- High prevalence of secondary bladder cancer in men on radiotherapy for prostate cancer: evidence from a meta-analysis.Cancer management and research · 2019Review
- Radiation-induced Non-targeted Effect and Carcinogenesis; Implications in Clinical Radiotherapy.Journal of biomedical physics & engineering · 2018Article
- Prostate cancer survivors: Risk and mortality in second primary cancers.Cancer medicine · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As patients with prostate cancer have a long life expectancy, there is increasing interest in predicting the risk of development of a second primary cancer (SPC), and we therefore designed this study to estimate the overall risk of developing SPCs among Korean prostate cancer patients. We used a population-based cohort from the Korean Central Cancer Registry composed of 55,378 men diagnosed with a first primary prostate cancer between 1993 and 2011. Standardized incidence ratios (SIRs) of SPCs were analyzed by age at diagnosis, latency period, period of diagnosis, and type of initial treatment. Survival analysis was stratified by development of SPC. Men with primary prostate cancer had an overall lower risk of developing an SPC [SIR = 0.75; 95% CI, 0.72-0.78], which was significant for SPCs of the esophagus, stomach, rectum, liver, gallbladder, bile duct, pancreas, larynx, lung, and bronchus. In contrast, there were significant increases in the risk of bladder and thyroid cancers, which tended to decrease after longer follow-up. Patients who received initial radiation therapy had an increased risk of subsequent rectal cancer, although this was still lower than that of the general male population. Other urinary tract cancers including those of the kidney, renal pelvis, and ureter tended to be associated with a higher risk of developing an SPC, but this difference did not reach statistical significance. The patients with prostate cancer and SPC had lower overall survival rates than those with one primary prostate cancer. Our findings suggest that men with prostate cancer have a 25% lower risk of developing an SPC in Korea, but a higher risk of developing subsequent bladder and thyroid cancers, which suggests the need for continued cancer surveillance among prostate cancer survivors.
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