ArticleScientific reports2015
Influence of a high-altitude hypoxic environment on human plasma microRNA profiles.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Decoding microRNA arm switching: a key to evolutionary innovation and gene regulation.Cellular and molecular life sciences : CMLS · 2025Review
- Review
- Identification of extremely GC-rich micro RNAs for RT-qPCR data normalization in human plasma.Frontiers in genetics · 2022Article
- Increased serum piwi-interacting RNAs as a novel potential diagnostic tool for brucellosis.Frontiers in cellular and infection microbiology · 2022Article
- Article
- Different expression pattern of human cytomegalovirus-encoded microRNAs in circulation from virus latency to reactivation.Journal of translational medicine · 2020Article
- HAHmiR.DB: a server platform for high-altitude human miRNA-gene coregulatory networks and associated regulatory circuits.Database : the journal of biological databases and curation · 2020Article
- Association ofBioMed research international · 2020Article
- Comprehensive analysis of differentially expressed serum microRNAs in humans responding toAnnals of translational medicine · 2019Article
- Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review.EJIFCC · 2019Review
- Circulating miRNA Profiling of Women at High Risk for Ovarian Cancer.Translational oncology · 2019Article
- Could genetic and epigenetic factors explain hypoxia tolerance and superior muscle performance of Sherpas at high-altitude?The Journal of physiology · 2019Article
- miRNA array analysis of plasma miRNA alterations in rats exposed to a high altitude hypoxic environment.Molecular medicine reports · 2018Article
- Role of miRNAs in hypoxia-related disorders.Journal of biosciences · 2018Review
- Different Erythrocyte MicroRNA Profiles in Low- and High-Altitude Individuals.Frontiers in physiology · 2018Article
- Genome-wide Long Non-coding RNA Analysis Identified Circulating LncRNAs as Novel Non-invasive Diagnostic Biomarkers for Gynecological Disease.Scientific reports · 2016Article
- Physiological Adjustments and Circulating MicroRNA Reprogramming Are Involved in Early Acclimatization to High Altitude in Chinese Han Males.Frontiers in physiology · 2016Article
- Similar Responses of Circulating MicroRNAs to Acute High-Intensity Interval Exercise and Vigorous-Intensity Continuous Exercise.Frontiers in physiology · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulating microRNAs (miRNAs) are promising disease biomarkers. However, the influence of high-altitude hypoxic environments on plasma miRNA profiles remains unknown. This study included a total of 509 plasma samples from 278 native Tibetans and 80 newly arrived migrant Han Chinese (Tibet Han) residing at 3560 m and 151 Han Chinese residing at 8.9 m (Nanjing Han). The levels of 754 miRNAs were initially determined using a TaqMan Low Density Array (TLDA) in two pooled samples from 50 Tibet Han and 50 Nanjing Han individuals. Some markedly altered miRNAs in Tibet Han were subsequently measured in all 509 plasma samples by individual qRT-PCR. Compared with the Nanjing Han, 172 miRNAs were differentially expressed in the Tibet Han (105 upregulated and 67 downregulated). The correlation coefficient for the two groups was 0.72. Several upregulated miRNAs were randomly selected for analysis by qRT-PCR, and the results were consistent with those identified by TLDA. These miRNAs were also significantly increased in the Tibetans compared with the Nanjing Han. Furthermore, these altered miRNAs showed strong positive correlations with red blood cell counts and hemoglobin values. These data are the first to provide clear evidence that a high-altitude hypoxic environment significantly affects human plasma miRNA profiles.
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