ArticleScientific reports2015
Time-Specific Fear Acts as a Non-Photic Entraining Stimulus of Circadian Rhythms in Rats.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Feeding a Diurnal Rodent at Night Induces Weight Loss and Body Temperature Reduction Without Food-Anticipatory Activity.Journal of biological rhythms · 2026Article
- Seasonal variation in activity rhythms of leopard cats (Prionailurus bengalensis), their prey and competitors in southern Anhui.Scientific reports · 2026Article
- Chrono-physiological management protocol in form of simultaneous shifting of lighting-cycle and feeding-time can enhance production performance of heat-stressed goat kids.Journal of animal science and technology · 2025Article
- Dark-phase melatonin administration does not reduce blood pressure but induces changes in parameters related to the control of the cardiovascular system in spontaneously hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- A stress-sensing circuit signals to the central pacemaker to reprogram circadian rhythms.Science advances · 2025Article
- Daytime aversive stimuli do not phase shift behavioral rhythms under light-dark cycles in a strictly diurnal rodent.Journal of biological rhythms · 2025Article
- One Health: Circadian Medicine Benefits Both Non-human Animals and Humans Alike.Journal of biological rhythms · 2024Review
- The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Acute stress persistently alters instrumental motivation without affecting appetitive Pavlovian conditioning, extinction, or contextual renewal.Neurobiology of learning and memory · 2023Article
- Many faces of sleep regulation: beyond the time of day and prior wake time.The FEBS journal · 2023Review
- Potential interactions between cerebellar dysfunction and sleep disturbances in dystonia.Dystonia (Lausanne, Switzerland) · 2022Article
- Lateral Habenula Beyond Avoidance: Roles in Stress, Memory, and Decision-Making With Implications for Psychiatric Disorders.Frontiers in systems neuroscience · 2022Article
- Shedding light on the circadian clock of the threespine stickleback.The Journal of experimental biology · 2021Article
- Commentary: The Risky Closed Economy: A Holistic, Longitudinal Approach to Studying Fear and Anxiety in Rodents.Frontiers in behavioral neuroscience · 2021Article
- Circadian regulation of membrane physiology in neural oscillators throughout the brain.The European journal of neuroscience · 2020Review
- The Risky Closed Economy: A Holistic, Longitudinal Approach to Studying Fear and Anxiety in Rodents.Frontiers in behavioral neuroscience · 2020Article
- Variation in chronotype is associated with migratory timing in a songbird.Biology letters · 2019Article
- The Role of Learning in Threat Imminence and Defensive Behaviors.Current opinion in behavioral sciences · 2018Article
- Flexible clock systems: adjusting the temporal programme.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Chronobiology of interspecific interactions in a changing world.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Virtually all animals have endogenous clock mechanisms that "entrain" to the light-dark (LD) cycle and synchronize psychophysiological functions to optimal times for exploring resources and avoiding dangers in the environment. Such circadian rhythms are vital to human mental health, but it is unknown whether circadian rhythms "entrained" to the LD cycle can be overridden by entrainment to daily recurring threats. We show that unsignaled nocturnal footshock caused rats living in an "ethological" apparatus to switch their natural foraging behavior from the dark to the light phase and that this switch was maintained as a free-running circadian rhythm upon removal of light cues and footshocks. Furthermore, this fear-entrained circadian behavior was dependent on an intact amygdala and suprachiasmatic nucleus. Thus, time-specific fear can act as a non-photic entraining stimulus for the circadian system, and limbic centers encoding aversive information are likely part of the circadian oscillator network that temporally organizes behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.