ArticleNature communications2015
Formation of functional super-helical assemblies by constrained single heptad repeat.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Application of photodynamic activation of prodrugs combined with phototherapy in tumor treatment.Molecular cancer · 2025Review
- Article
- Design of stimuli-responsive minimalist heptad surfactants for stable emulsions.Communications materials · 2024Article
- Glycopeptide-Based Supramolecular Hydrogels Induce Differentiation of Adipose Stem Cells into Neural Lineages.ACS applied materials & interfaces · 2023Article
- A Structural Analysis of Proteinaceous Nanotube Cavities and Their Applications in Nanotechnology.Nanomaterials (Basel, Switzerland) · 2022Review
- Peptide-based nanomaterials: Self-assembly, properties and applications.Bioactive materials · 2022Review
- Intrinsically Disordered Tardigrade Proteins Self-Assemble into Fibrous Gels in Response to Environmental Stress.Angewandte Chemie (International ed. in English) · 2022Article
- Recent advances in self-assembling peptide matrices as functional coatings for implantable devices.Frontiers in chemistry · 2022Review
- Self-Assembling Peptides: From Design to Biomedical Applications.International journal of molecular sciences · 2021Review
- Molecular design of stapled pentapeptides as building blocks of self-assembled coiled coil-like fibers.Science advances · 2021Article
- The Human LL-37(17-29) antimicrobial peptide reveals a functional supramolecular structure.Nature communications · 2020Article
- Supramolecular Peptide Assemblies as Antimicrobial Scaffolds.Molecules (Basel, Switzerland) · 2020Review
- Structure and Aggregation Mechanisms in Amyloids.Molecules (Basel, Switzerland) · 2020Review
- Functional Coiled-Coil-like Assembly by Knob-into-Hole Packing of Single Heptad Repeat.ACS nano · 2019Article
- Designing stable, hierarchical peptide fibers from block co-polypeptide sequences.Chemical science · 2019Article
- Hierarchically oriented organization in supramolecular peptide crystals.Protein and peptide letters · 2019Article
- Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly.ACS nano · 2019Article
- Stoichiometry-controlled secondary structure transition of amyloid-derived supramolecular dipeptide co-assemblies.Communications chemistry · 2019Article
- Rigid helical-like assemblies from a self-aggregating tripeptide.Nature materials · 2019Article
- Minimalistic supramolecular proteoglycan mimics by co-assembly of aromatic peptide and carbohydrate amphiphiles.Chemical science · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inspired by the key role of super-helical motifs in molecular self-organization, several tandem heptad repeat peptides were used as building blocks to form well-ordered supramolecular nano-assemblies. However, the need for stable helical structures limits the length of the smallest described units to three heptad repeats. Here we describe the first-ever self-assembling single heptad repeat module, based on the ability of the non-coded α-aminoisobutyric acid to stabilize very short peptides in helical conformation. A conformationally constrained peptide comprised of aromatic, but not aliphatic, residues, at the first and fourth positions formed helical fibrillar assemblies. Single crystal X-ray analysis of the peptide demonstrates super-helical packing in which phenylalanine residues formed an 'aromatic zipper' arrangement at the molecular interface. The modification of the minimal building block with positively charged residues results in tight DNA binding ascribed to the combined factors of helicity, hydrophobicity and charge. The design of these peptides defines a new direction for assembly of super-helical nanostructures by minimal molecular elements.
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