Evidence map›Paper›PMID 26468520›Full record

ArticleJournal of virology2016

Proton Channel Activity of Influenza A Virus Matrix Protein 2 Contributes to Autophagy Arrest.

Yizhong Ren, Chufang Li, Liqiang Feng, Weiqi Pan, Liang Li, Qian Wang, Jiashun Li, Na Li, Ling Han, Xuehua Zheng and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
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  14. mBio · 2021
    Article
  15. Sarco/Endoplasmic Reticulum CaJournal of virology · 2021
    Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Yizhong RenSchool of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health, Guangzhou, Guangdong, China.
Chufang LiState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China chen_ling@gibh.ac.cn li_chufang@163.com.
Liqiang FengState Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health, Guangzhou, Guangdong, China.
Weiqi PanState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Liang LiState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Qian WangState Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health, Guangzhou, Guangdong, China.
Jiashun LiState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Na LiState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Ling HanState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Xuehua ZhengState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Xuefeng NiuState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Caijun SunState Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health, Guangzhou, Guangdong, China.
Ling ChenState Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health, Guangzhou, Guangdong, China chen_ling@gibh.ac.cn li_chufang@163.com.
Guangzhou Medical University · CNState Key Laboratory of Respiratory Disease · CNGuangzhou Institutes of Biomedicine and Health · CNFirst Affiliated Hospital of Guangzhou Medical University · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus matrix protein 2 (M2). Thus, M2 proton channel activity plays a role in blocking the fusion of autophagosomes with lysosomes, which might be a key mechanism for arresting autophagy.

Indexed as

AutophagyHost-Pathogen InteractionsHumansInfluenza A virusProtonsViral Matrix ProteinsViroporin ProteinsM2 protein, Influenza A virusProtonsViral Matrix ProteinsViroporin Proteins

Identifiers

PMID26468520
PMCPMC4702553
OpenAlexW2285592953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.