Evidence map›Paper›PMID 26468474›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2015

Basal ganglia T1 hyperintensity in LGI1-autoantibody faciobrachial dystonic seizures.

Eoin P Flanagan, Amy L Kotsenas, Jeffrey W Britton, Andrew McKeon, Robert E Watson, Christopher J Klein, Bradley F Boeve, Val Lowe, J Eric Ahlskog, Cheolsu Shin and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 3 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 3 syntheses or guidelines pooled it, 209 citations in OpenAlex.

  1. Pooled it
  2. BrainEuropean journal of nuclear medicine and molecular imaging · 2021
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Eoin P FlanaganDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Amy L KotsenasDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Jeffrey W BrittonDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Andrew McKeonDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Robert E WatsonDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Christopher J KleinDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Bradley F BoeveDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Val LoweDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
J Eric AhlskogDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Cheolsu ShinDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Christopher J BoesDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Brian A CrumDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Ruple S LaughlinDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Sean J PittockDepartment of Neurology (E.P.F., J.W.B., A.M., C.J.K., B.F.B., J.E.A., C.S., C.J.B., B.A.C., R.S.L., S.J.P.), Department of Radiology (A.L.K., R.E.W., V.L.), and Department of Laboratory Medicine and Pathology (A.M., C.J.K., S.J.P.), Mayo Clinic, Rochester, MN.
Jisc · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo characterize the clinical features and MRI abnormalities of leucine-rich glioma-inactivated 1 (LGI1)-autoantibody (Ab) faciobrachial dystonic seizures (FBDS).

methodsForty-eight patients with LGI1-Ab encephalopathy were retrospectively identified by searching our clinical and serologic database from January 1, 2002, to June 1, 2015. Of these, 26 met inclusion criteria for this case series: LGI1-Ab seropositivity and FBDS. In a separate analysis of all 48 patients initially identified, the MRIs of patients with (n = 26) and without (n = 22) FBDS were compared by 2 neuroradiologists blinded to the clinical details.

resultsThe median age of the 26 included patients was 62.5 years (range 37-78); 65% were men. FBDS involved arm (26), face (22), and leg (12). Ten were previously diagnosed as psychogenic. Ictal EEGs were normal in 20 of 23 assessed. Basal ganglia T1 and T2 signal abnormalities were detected in 11 patients (42%), with excellent agreement between neuroradiologists (κ scores of 0.86 and 0.93, respectively), and included T1 hyperintensity alone (2), T2 hyperintensity alone (1), or both (8). The T1 hyperintensities persisted longer than the T2 hyperintensities (median 11 weeks vs 1 week, p = 0.02). Improvement with immunotherapy (18/18) was more frequent than with antiepileptic medications (10/24). A separate analysis of all 48 patients initially identified with LGI1-Ab encephalopathy showed that basal ganglia MRI abnormalities were present in 11 of 26 with FBDS but not present in those without FBDS (0/22) (p < 0.001). In contrast, mesial temporal MRI abnormalities were less common among those with FBDS (42%) than those without (91%) (p < 0.001).

conclusionsBasal ganglia T1 hyperintensity is a clinically useful MRI biomarker of LGI1-Ab FBDS and suggests a basal ganglia localization.

Identifiers

PMID26468474
PMCPMC4592539
OpenAlexW2098839264

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