ArticleAvicenna journal of phytomedicine
Effects of crocin and safranal, saffron constituents, on the formalin-induced orofacial pain in rats.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Functional, Nutraceutical and Health Endorsing Perspectives of Saffron.Food science & nutrition · 2025Review
- Ethnobotany and phytochemistry of plants used to treat musculoskeletal disorders among Skaw Karen, Thailand.Pharmaceutical biology · 2024Article
- From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design.Molecules (Basel, Switzerland) · 2024Review
- Involvement of Oxidative Stress and Nutrition in the Anatomy of Orofacial Pain.International journal of molecular sciences · 2023Review
- The Interactions of Magnesium Sulfate and Cromoglycate in a Rat Model of Orofacial Pain; The Role of Magnesium on Mast Cell Degranulation in Neuroinflammation.International journal of molecular sciences · 2023Article
- Article
- Pharmacological effects of Safranal: An updated review.Iranian journal of basic medical sciences · 2023Review
- Crocin averts functional and structural rat hepatic disturbances induced by copper oxide nanoparticles.Toxicology research · 2022Article
- Carotenoids in Palliative Care-Is There Any Benefit fromNutrients · 2022Review
- Saffron nephroprotective effects against medications and toxins: A review of preclinical data.Iranian journal of basic medical sciences · 2022Review
- Inhibitory effects of safranal on laser-induced choroidal neovascularization and human choroidal microvascular endothelial cells and related pathways analyzed with transcriptome sequencing.International journal of ophthalmology · 2021Article
- Crocin prevents metabolic syndrome in rats via enhancing PPAR-gamma and AMPK.Saudi journal of biological sciences · 2020Article
- Central HVeterinary research forum : an international quarterly journal · 2020Article
- TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal.Journal of cellular and molecular medicine · 2019Article
- (-)-α-Bisabolol reduces orofacial nociceptive behavior in rodents.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Effects of intra-fourth ventricle injection of crocin on capsaicin-induced orofacial pain in rats.Avicenna journal of phytomedicineArticle
- Saffron offers hepatoprotection via up-regulation of hepatic farnesoid-X-activated receptors in a rat model of acetaminophen-induced hepatotoxicity.Avicenna journal of phytomedicineArticle
- Intra-cerebroventricular Administration of Crocin Attenuates Sleep Deprivation-induced Hyperalgesia in Rats.Basic and clinical neuroscienceArticle
- Histopathological and behavioral evaluations of the effects of crocin, safranal and insulin on diabetic peripheral neuropathy in rats.Avicenna journal of phytomedicineArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCrocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. MATERIALS AND
methodsSubcutaneous injection of a diluted formalin solution (50 µl, 1.5%) into the upper lip region produced a biphasic pattern of pain response (a neurogenic phase: 0-3 min and an inflammatory phase: 15-33 min). The time each animal spent face rubbing with ipsilateral forepaw was recorded and considered as an index of nociception.
resultsIntraperitoneal injections of crocin (12.5 and 25 mg/kg), safranal (0.25 and 0.5 mg/kg), diclofenac (5 and 10 mg/kg) and morphine (1 and 2 mg/kg) suppressed the second phase of pain. The second phase of pain was also reduced when low (ineffective) doses of crocin (6.25 mg/kg) and safranal (0.125 mg/kg) were co-administered with low doses of diclofenac (2.5 mg/kg) and morphine (0.5 mg/kg). The more antinociceptive effects were observed when the medium doses of the above-mentioned chemicals used together. Naloxone prevented morphine-induced antinociception, but did not inhibit the suppressive effects of crocin and safranal. Safranal at a high dose (0.5 mg/kg) suppressed locomotor activity.
conclusionThe present results showed antinociceptive effects for crocin and safranal in inflammatory pain. Opioid receptors may not be involved in the antinociceptive effect of crocin and safranal. Crocin and safranal increased diclofenac-induced antinociception.
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26468458PMC4599115W1665775627What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.