ReviewJournal of clinical pathology2016
Traditional serrated adenomas of the upper digestive tract.
Review in Journal of clinical pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Two duodenal sessile serrated lesions in a patient with serrated polyposis syndrome: case report and review of the literature.Clinical journal of gastroenterology · 2025Review
- A case report of gastric serrated adenoma arising in a patient with bile reflux gastritis and related literature review.Frontiers in oncology · 2025Article
- Traditional Serrated Adenoma of the Gallbladder, a Case Report.Pathology oncology research : POR · 2022Article
- Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations.International journal of molecular sciences · 2021Review
- Duodenal sessile serrated adenoma/polyp with characteristic endoscopic and pathologic features.Clinical journal of gastroenterology · 2021Article
- Gastric and small intestinal traditional serrated adenomas: a detailed morphologic and immunohistochemical analysis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Mitochondrial DNA variants in colorectal carcinogenesis: Drivers or passengers?Journal of cancer research and clinical oncology · 2017Review
- Critical Role of p53 and K-ras in the Diagnosis of Early Colorectal Cancer: a One-year, Single-center Analysis.International journal of medical sciences · 2017Article
- Clinical features of upper gastrointestinal serrated lesions: An endoscopy database analysis of 98746 patients.World journal of gastroenterology · 2016Article
- Pathophysiological and clinical aspects of gastric hyperplastic polyps.World journal of gastroenterology · 2016Review
- Jejunal Serrated Adenoma Diagnosed and Treated by Double-Balloon Enteroscopy.Case reports in gastroenterologyArticle
- Slow-Growing Early Adenocarcinoma Arising from Traditional Serrated Adenoma in the Duodenum.Case reports in gastroenterologyArticle
- Traditional Serrated Adenoma of the Ileum with Intussusception Successfully Treated with Laparoscopic Bowel Resection.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For many years, it was generally accepted that the vast majority of the colorectal carcinomas (CRCs) evolved from conventional adenomas, via the adenoma-carcinoma sequence. More recently, serrated colorectal polyps (hyperplastic polyps, sessile serrated polyps and traditional serrated adenomas (TSAs)) have emerged as an alternative pathway of colorectal carcinogenesis. It has been estimated that about 30% of the CRC progress via the serrated pathway. Recently, TSAs were also detected in the upper digestive tract. In this work, we review the literature on TSA in the oesophagus, the stomach, the duodenum, the pancreatic main duct and the gallbladder. The review indicated that 53.4% (n=39) out of the 73 TSA of the upper digestive tract now in record showed a simultaneously growing invasive carcinoma. As a corollary, TSAs of the upper digestive tract are aggressive adenomas that should be radically excised, either endoscopically or surgically, to rule out the possibility of a synchronously growing invasive adenocarcinoma or to prevent cancer progression. The present findings substantiate a TSA pathway of carcinogenesis in the upper digestive tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.