ArticleGastroenterology and hepatology from bed to bench2015
Combination of erythromycin and propranolol for treatment of childhood cyclic vomiting syndrome: a novel regimen.
Article in Gastroenterology and hepatology from bed to bench, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Cyclic Vomiting Syndrome in Children.Frontiers in neurology · 2020Pooled it
- Relapse Rate of Clinical Symptoms After Stopping Treatment in Children with Cyclic Vomiting Syndrome.Middle East journal of digestive diseases · 2023Article
- Seizure Induced by Defecation in a 15-Year Old Autistic Patient: A Case Report and Literature Review.Iranian journal of child neurology · 2020Article
- Managing cyclic vomiting syndrome in children: beyond the guidelines.European journal of pediatrics · 2018Review
- Cyclic Vomiting Syndrome in Children and Adults: What Is New in 2018?Current gastroenterology reports · 2018Review
- Cyclic Vomiting Syndrome in Children.Current pain and headache reports · 2018Review
- Cyclic vomiting syndrome: diagnostic approach and current management strategies.Clinical and experimental gastroenterology · 2018Review
- Cyclic vomiting syndrome: a case series and review of the literature.Frontline gastroenterology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to evaluate the erythromycin efficacy in childhood cyclic vomiting syndrome.
backgroundCyclic vomiting syndrome (CVS) is an unusual cause of episodic emesis in children and erythromycin is an effective treatment. PATIENTS AND
methodsIn this prospective study, 301 patients with a final diagnosis of CVS enrolled in two separated groups. The first group received erythromycin for 7 days and propranolol for at least 9 months (n=155). The second group was treated with propranolol alone for at least 9 months (n=146). These two groups were compared for response to the treatment and the recurrence of symptoms after treatment completion. Relationship of response, recurrence, and characteristics of the disease was assessed.
resultsBoth groups showed a significant difference in terms of response to treatment (P=0.002), however the recurrence after treatment completion had no considerable difference (P=0.563). There was no relationship between CVS characteristics and these two items (response and recurrence).
conclusionIn our point of view, the addition of erythromycin to standard propranolol treatment can improve the response to treatment, although it has no significant effect on recurrence of CVS symptoms. We suggest the use of erythromycin for 7 days in addition to CVS standard therapy.
Indexed as
Identifiers
26468347PMC4600517W2145679396What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.