ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Arc-Expressing Neuronal Ensembles Supporting Pattern Separation Require Adrenergic Activity in Anterior Piriform Cortex: An Exploration of Neural Constraints on Learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Second-order threat conditioning in the amygdala-posterior piriform cortex network.Communications biology · 2025Article
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- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Norepinephrine depletion in the brain sex-dependently modulates aspects of spatial learning and memory in female and male rats.Psychopharmacology · 2023Article
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- Understanding Categorical Learning in Neural Circuits Through the Primary Olfactory Cortex.Frontiers in cellular neuroscience · 2022Article
- Noradrenergic Modulation of the Piriform Cortex: A Possible Avenue for Understanding Pre-Clinical Alzheimer's Disease Pathogenesis.Frontiers in cellular neuroscience · 2022Review
- Locus Coeruleus Optogenetic Modulation: Lessons Learned from Temporal Patterns.Brain sciences · 2021Article
- Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Locus Coeruleus Activation Patterns Differentially Modulate Odor Discrimination Learning and Odor Valence in Rats.Cerebral cortex communications · 2021Article
- β-adrenergic modulation of discrimination learning and memory in the auditory cortex.The European journal of neuroscience · 2019Article
- An experimental model of Braak's pretangle proposal for the origin of Alzheimer's disease: the role of locus coeruleus in early symptom development.Alzheimer's research & therapy · 2019Article
- Aversive learning-induced plasticity throughout the adult mammalian olfactory system: insights across development.Journal of bioenergetics and biomembranes · 2019Review
- Pheromone-Induced Odor Associative Fear Learning in Rats.Scientific reports · 2018Article
- Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation.Frontiers in cellular neuroscience · 2018Article
- The Role of L-type Calcium Channels in Olfactory Learning and Its Modulation by Norepinephrine.Frontiers in cellular neuroscience · 2017Article
- GANEing traction: The broad applicability of NE hotspots to diverse cognitive and arousal phenomena.The Behavioral and brain sciences · 2016Article
- Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?Frontiers in synaptic neuroscience · 2016Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Arc ensembles in adult rat olfactory bulb (OB) and anterior piriform cortex (PC) were assessed after discrimination training on highly similar odor pairs. Nonselective α- and β-adrenergic antagonists or saline were infused in the OB or anterior PC during training. OB adrenergic blockade slowed, but did not prevent, odor discrimination learning. After criterion performance, Arc ensembles in anterior piriform showed enhanced stability for the rewarded odor and pattern separation for the discriminated odors as described previously. Anterior piriform adrenergic blockade prevented acquisition of similar odor discrimination and of OB ensemble changes, even with extended overtraining. Mitral and granule cell Arc ensembles in OB showed enhanced stability for rewarded odor only in the saline group. Pattern separation was not seen in the OB. Similar odor discrimination co-occurs with increased stability in rewarded odor representations and pattern separation to reduce encoding overlap. The difficulty of similar discriminations may relate to the necessity to both strengthen rewarded representations and weaken overlap across similar representations. SIGNIFICANCE STATEMENT: We show for the first time that adrenoceptors in anterior piriform cortex (aPC) must be engaged for adult rats to learn to discriminate highly similar odors. Loss of adrenergic activation in olfactory bulb (OB) slows, but does not prevent, discrimination learning. Both increased stability of the rewarded odor representation and increased pattern separation of the rewarded and unrewarded odors in aPC accompany successful discrimination. In the OB, rewarded odors increase in ensemble stability, but there is no evidence of pattern separation. We suggest that the slow acquisition of similar odor discriminations is related to the differing plasticity requirements for increased stability and pattern separation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.