ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
New Perspectives for the Rescue of Cognitive Disability in Down Syndrome.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Future Perspectives in Oxidative Stress in Trisomy 13 and 18 Evaluation.Journal of clinical medicine · 2022Review
- Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments.Frontiers in neuroscience · 2022Article
- Influence of COVID-19 pandemic lockdown on a sample of Egyptian children with Down syndrome.The Egyptian journal of medical human genetics · 2022Article
- Evaluating the Risks and Benefits of Genetic and Pharmacologic Interventions for Down Syndrome: Views of Parents.American journal on intellectual and developmental disabilities · 2020Article
- Enhanced Dendritic Inhibition and Impaired NMDAR Activation in a Mouse Model of Down Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities.Translational psychiatry · 2019Article
- Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells.Frontiers in genetics · 2019Article
- The Arizona Cognitive Test Battery for Down Syndrome: Test-Retest Reliability and Practice Effects.American journal on intellectual and developmental disabilities · 2017Article
- Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer's-like memory deficits in the Ts65Dn mouse model of Down syndrome.Scientific reports · 2017Article
- Expanding Use of cfDNA Screening in Pregnancy: Current and Emerging Ethical, Legal, and Social Issues.Current genetic medicine reports · 2017Article
- Inflammation-induced miRNA-155 inhibits self-renewal of neural stem cells via suppression of CCAAT/enhancer binding protein β (C/EBPβ) expression.Scientific reports · 2017Article
- Article
- Modeling Fragile X syndrome in neurogenesis: An unexpected phenotype and a novel tool for future therapies.Neurogenesis (Austin, Tex.) · 2017Article
- Mouse models of Down syndrome: gene content and consequences.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Treating trisomies: Prenatal Down's syndrome therapies explored in mice.Nature medicine · 2016Article
- "Down Syndrome is Not a Curse": parent Perspectives on the Medicalization of Down Syndrome.AJOB empirical bioethicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.