ArticleJournal of the Royal Society, Interface2015
Conflict and cooperation in eukaryogenesis: implications for the timing of endosymbiosis and the evolution of sex.
Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- Evolutionary codependency: insights into the mitonuclear interaction landscape from experimental and wild Caenorhabditis nematodes.Current opinion in genetics & development · 2023Review
- Review
- SymbiQuant: A Machine Learning Object Detection Tool for Polyploid Independent Estimates of Endosymbiont Population Size.Frontiers in microbiology · 2022Article
- Adaptive mitochondrial response of the whiteleg shrimp Litopenaeus vannamei to environmental challenges and pathogens.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Article
- The conflict within: origin, proliferation and persistence of a spontaneously arising selfish mitochondrial genome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Mitonuclear conflict and cooperation govern the integration of genotypes, phenotypes and environments.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Evolving mtDNA populations within cells.Biochemical Society transactions · 2019Review
- Selfish Mitonuclear Conflict.Current biology : CB · 2019Review
- Fishing for adaptive epistasis using mitonuclear interactions.PLoS genetics · 2017Article
- Mitochondria, the Cell Cycle, and the Origin of Sex via a Syncytial Eukaryote Common Ancestor.Genome biology and evolution · 2016Article
- Review
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2 authors.
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Abstract
Roughly 1.5-2.0 Gya, the eukaryotic cell evolved from an endosymbiosis of an archaeal host and proteobacterial symbionts. The timing of this endosymbiosis relative to the evolution of eukaryotic features remains subject to considerable debate, yet the evolutionary process itself constrains the timing of these events. Endosymbiosis entailed levels-of-selection conflicts, and mechanisms of conflict mediation had to evolve for eukaryogenesis to proceed. The initial mechanisms of conflict mediation (e.g. signalling with calcium and soluble adenylyl cyclase, substrate carriers, adenine nucleotide translocase, uncouplers) led to metabolic homeostasis in the eukaryotic cell. Later mechanisms (e.g. mitochondrial gene loss) contributed to the chimeric eukaryotic genome. These integral features of eukaryotes were derived because of, and therefore subsequent to, endosymbiosis. Perhaps the greatest opportunity for conflict arose with the emergence of eukaryotic sex, involving whole-cell fusion. A simple model demonstrates that competition on the lower level severely hinders the evolution of sex. Cytoplasmic mixing, however, is beneficial for non-cooperative endosymbionts, which could have used their aerobic metabolism to manipulate the life history of the host. While early evolution of sex may have facilitated symbiont acquisition, sex would have also destabilized the subsequent endosymbiosis. More plausibly, the evolution of sex and the true nucleus concluded the transition.
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