Evidence map›Paper›PMID 26467974›Full record

ReviewImmunologic research2015

The Genotype and Phenotype (GaP) registry: a living biobank for the analysis of quantitative traits.

Peter K Gregersen, Gila Klein, Mary Keogh, Marlena Kern, Margaret DeFranco, Kim R Simpfendorfer, Sun Jung Kim, Betty Diamond

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Investigations intoLupus science & medicine · 2021
    Article
  5. Article
  6. Article
  7. Menstruation: science and society.American journal of obstetrics and gynecology · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Recent Advances in Defining the Genetic Basis of Rheumatoid Arthritis.Annual review of genomics and human genetics · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter K GregersenRobert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA. peterg@nshs.edu.
Gila KleinRobert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Mary KeoghRobert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Marlena KernRobert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Margaret DeFrancoRobert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Kim R SimpfendorferRobert S. Boas Center for Genomics and Human Genetics, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Sun Jung KimCenter for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
Betty DiamondCenter for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the development of the Genotype and Phenotype (GaP) Registry, a living biobank of normal volunteers who are genotyped for genetic markers related to human disease. Participants in the GaP can be recalled for hypothesis driven study of disease associated genetic variants. The GaP has facilitated functional studies of several autoimmune disease associated loci including Csk, Blk, PDRM1 (Blimp-1) and PTPN22. It is likely that expansion of such living biobank registries will play an important role in studying and understanding the function of disease associated alleles in complex disease.

Indexed as

Quantitative Trait, HeritableRegistriesAutoimmune DiseasesBiological Specimen BanksCSK Tyrosine-Protein KinaseGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansMicroRNAsPhenotypePolymorphism, GeneticPositive Regulatory Domain I-Binding Factor 1Protein Tyrosine Phosphatase, Non-Receptor Type 22Repressor Proteinssrc-Family KinasesBLK protein, humanCSK protein, humanCSK Tyrosine-Protein KinaseMicroRNAsPositive Regulatory Domain I-Binding Factor 1PRDM1 protein, humanProtein Tyrosine Phosphatase, Non-Receptor Type 22PTPN22 protein, humanRepressor Proteinssrc-Family KinasesAutoimmune diseaseBiorepositoryEndophenotypeGWAS

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.