Evidence map›Paper›PMID 26467973›Full record

ReviewImmunologic research2015

Integrative neuroscience approach to neuropsychiatric lupus.

Patricio T Huerta, Elizabeth L Gibson, Carson Rey, Tomás S Huerta

Abstract readReview
In one paragraph

Review in Immunologic research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The Impact of Vitamin D on Cognitive Dysfunction in Mice with Systemic Lupus Erythematosus.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Patricio T HuertaLaboratory of Immune and Neural Networks, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA. pato.huerta@gmail.com.
Elizabeth L GibsonLaboratory of Immune and Neural Networks, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Carson ReyLaboratory of Immune and Neural Networks, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Tomás S HuertaLaboratory of Immune and Neural Networks, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Feinstein Institute for Medical Research · US

Funding

The Monoclonal Antibody and Reagent CoreP01AI073693 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Cynthia Aranow · 2008 to 2026
$45.8M
Targeting cognitive and immune impairment in sepsis survivorsP01AI102852 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI VOLPE, BRUCE THOMAS · 2014 to 2018
$11.5M
NIAID NIH HHS P01 AI073693NIAID NIH HHS P01-AI073693NIAID NIH HHS P01 AI102852NIAID NIH HHS P01-AI102852
6 · The paper itself

Abstract

We present a succinct review of our approach to study the interactions between the DNA-reactive antibodies that cross-react with the GluN2A and GluN2B subunits of the N-methyl-D-aspartate receptor, denoted DNRABs, and their brain targets in subjects with neuropsychiatric systemic lupus erythematosus (NPSLE). We have analyzed the DNRAB-based brain symptomatology in mouse models of NPSLE by using an integrative neuroscience approach, which includes behavioral assessment coupled with electrophysiological studies of neural networks and synaptic connections in target brain regions, such as the CA1 region of the hippocampus. Our results suggest a framework for understanding the interactions between immune factors and neural networks.

Indexed as

AnimalsAntibodies, AntinuclearCA1 Region, HippocampalCognition DisordersCross ReactionsHumansLupus Erythematosus, SystemicMiceNerve NetNeuroimmunomodulationReceptors, N-Methyl-D-AspartateAntibodies, AntinuclearNR2B NMDA receptorReceptors, N-Methyl-D-AspartateBrain autoimmunityCognitionHippocampusMouseNMDAR

Identifiers

PMID26467973
PMCPMC4918503
OpenAlexW2164089882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.