ArticleJournal of human hypertension2016
Relationship between C242T polymorphism and arterial stiffness in an apparently healthy population.
Article in Journal of human hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Factors associated with high brachial-ankle pulse wave velocity in non-hypertensive and appropriately treated hypertensive patients with atherosclerotic risk factors.Vascular health and risk management · 2017Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Superoxide production is modulated by the C242T polymorphism of the CYBA gene. A major source of the superoxide anion that contributes to arterial stiffness is oxidase. We investigated the relationship between the C242T polymorphism and brachial-ankle pulse wave velocity (baPWV) in an apparently healthy population, while controlling for the amount of consumed cigarette. We measured baPWV non-invasively, recorded the detailed history of smoking and genotyped the C242T polymorphism in 856 participants. The CC genotype was related to a higher value of baPWV than the CT/TT genotype (1438.7±11.9 vs 1371.0±32.4 cm s(-1), β=-0.069, P=0.03) after adjustment for covariates. Further investigation showed an interaction between C242T polymorphism and smoking status with respect to baPWV (P<0.0001). For smokers, the CC genotype of C242T polymorphism was correlated with higher baPWV values compared with CT/TT genotype (1344.2±17.4 vs 1126.8±22.5 cm s(-1), β=-0.279, P<0.0001), whereas this relationship in the non-smokers was not significant (1485.5±15.1 vs 1499.0±41.5 cm s(-1), β=0.027, P=0.48). Additionally, for smokers who smoked at least 180 cigarette-years, the CC genotype participants showed higher values of baPWV compared with CT/TT polymorphism carriers (P⩽0.011). Our findings suggest that the C242T gene polymorphism is associated with arterial stiffness. Additionally, this relationship could be modified by smoking dose.
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