ArticleBMC psychiatry2015
Direct and indirect influences of childhood abuse on depression symptoms in patients with major depressive disorder.
Article in BMC psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of the Association Between Childhood Maltreatment and Adult Depression.Acta psychiatrica Scandinavica · 2025Pooled it
- Psychological Mediators of the Association Between Childhood Emotional Abuse and Depression: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Major Depressive Disorder and Serum Inflammatory Biomarkers as Predictors of Reward-Processing Dysfunction in an American Indian Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- A Longitudinal Study on Predicting Treatment Response in Depression Using Self-Reported Symptoms.Journal of Korean medical science · 2026Article
- Pervasive neurovascular dysfunction in the ventromedial prefrontal cortex of female depressed suicides with a history of childhood abuse.Molecular psychiatry · 2026Article
- The Relationship Between Childhood Abuse, Personality, and Depression: A Narrative Review.Alpha psychiatry · 2025Review
- Article
- Associations between pulmonary function and depression: evidence from the CHARLS cohort 2015-2018.Frontiers in public health · 2025Article
- Interrelationships Among Personality Traits, Depressive Symptoms, Childhood Abuse, and Social Disability.Depression and anxiety · 2025Article
- Mediation effects of subjective social status and personality traits between childhood nurturing experiences and depressive symptoms in adult volunteers.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Effects of Inappropriate Nurturing Experiences, Depressive Rumination, and Trait Anxiety on Depressive Symptoms.Neuropsychiatric disease and treatment · 2024Article
- Positive Childhood Experiences and Adult Health Outcomes.Pediatrics · 2023Article
- The Effect of Child Trauma on the Relation between Psychological Well-Being and Depressive Symptoms in Chilean University Students.Healthcare (Basel, Switzerland) · 2022Article
- Long-term effect of childhood trauma: Role of inflammation and white matter in mood disorders.Brain, behavior, & immunity - health · 2022Article
- The effects of childhood trauma on personality in unaffected first-degree relatives of patients with major depressive disorder.BMC psychiatry · 2022Article
- Migraine and Neuroticism: A Scoping Review.Behavioral sciences (Basel, Switzerland) · 2022Article
- Post-traumatic stress disorder, depression and the associated factors among children and adolescents with a history of maltreatment in Uganda.European journal of psychotraumatology · 2022Article
- Childhood Victimization and Neuroticism Mediate the Effects of Childhood Abuse on Adulthood Depressive Symptoms in Volunteers.Neuropsychiatric disease and treatment · 2022Article
- Using phenome-wide association studies and the SF-12 quality of life metric to identify profound consequences of adverse childhood experiences on adult mental and physical health in a Northern Nevadan population.Frontiers in psychiatry · 2022Article
- Increased Stress Resistance and Lifespan inMolecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is known that the onset, progression, and prognosis of major depressive disorder are affected by interactions between a number of factors. This study investigated how childhood abuse, personality, and stress of life events were associated with symptoms of depression in depressed people.
methodsPatients with major depressive disorder (N = 113, 58 women and 55 men) completed the Beck Depression Inventory-II (BDI-II), the Neuroticism Extroversion Openness Five Factor Inventory (NEO-FFI), the Child Abuse and Trauma Scale (CATS), and the Life Experiences Survey (LES), which are self-report scales. Results were analyzed with correlation analysis and structural equation modeling (SEM), by using SPSS AMOS 21.0.
resultsChildhood abuse directly predicted the severity of depression and indirectly predicted the severity of depression through the mediation of personality. Negative life change score of the LES was affected by childhood abuse, however it did not predict the severity of depression.
conclusionsThis study is the first to report a relationship between childhood abuse, personality, adulthood life stresses and the severity of depression in depressed patients. Childhood abuse directly and indirectly predicted the severity of depression. These results suggest the need for clinicians to be receptive to the possibility of childhood abuse in patients suffering from depression. SEM is a procedure used for hypothesis modeling and not for causal modeling. Therefore, the possibility of developing more appropriate models that include other variables cannot be excluded.
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