ReviewCurrent neuropharmacology2015
The Management and Outcomes of Pharmacological Treatments for Tinnitus.
Review in Current neuropharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03365011 (Nitrous Oxide as Treatment for Tinnitus), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- Expanding the Spectrum of Central Sensitivity Syndrome: Integrating Otologic Migraine as Otologic Central Sensitivity Syndrome.Brain sciences · 2026Review
- Inner ear signs and symptoms induced by antidepressants: a disproportionality analysis based on the FAERS database.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Mindfulness-based therapy for chronic tinnitus: a narrative review.Frontiers in psychology · 2026Review
- Acupuncture for chronic tinnitus: study protocol for a clinical trial with auditory brainstem response outcomes.Frontiers in neurology · 2026Article
- Digital Frequency Customized Relieving Sound for Chronic Subjective Tinnitus Management: Prospective Controlled Study.Journal of medical Internet research · 2025Article
- A scoping review of tinnitus research undertaken by New Zealand researchers: Aotearoa-an international hotspot for tinnitus innovation and collaboration.Journal of the Royal Society of New Zealand · 2025Review
- Treatment of Tinnitus with Intratympanic Injection of Dexamethasone Versus Oral Drugs.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- A Review on Peripheral Tinnitus, Causes, and Treatments from the Perspective of Autophagy.Experimental neurobiology · 2022Review
- A Chinese Medicine Formula (Bushen Huoxue Tongluo) for the Treatment of Chronic Subjective Tinnitus: A Study Protocol for a Pilot, Assessor-Blinded, Randomized Clinical Trial.Frontiers in pharmacology · 2022Article
- Phase I trial of caudate deep brain stimulation for treatment-resistant tinnitus.Journal of neurosurgery · 2020Article
- The potential interruptive effect of tinnitus-related distress on attention.Scientific reports · 2020Article
- Article
- Tinnitus services in the United Kingdom: a survey of patient experiences.BMC health services research · 2018Article
- Manipulation of Auditory Inputs as Rehabilitation Therapy for Maladaptive Auditory Cortical Reorganization.Neural plasticity · 2018Review
- Pairing sound with vagus nerve stimulation modulates cortical synchrony and phase coherence in tinnitus: An exploratory retrospective study.Scientific reports · 2017Article
- Broadened population-level frequency tuning in the auditory cortex of tinnitus patients.Journal of neurophysiology · 2017Article
- A Pilot Genome-Wide Association Study Identifies Potential Metabolic Pathways Involved in Tinnitus.Frontiers in neuroscience · 2017Article
- The missing pieces: an investigation into the parallels between Charles Bonnet, phantom limb and tinnitus syndromes.Therapeutic advances in ophthalmologyReview
- Which affective temperaments are most expressed in patients with chronic sub-jective tinnitus?HippokratiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus, a phantom sensation experienced by people around the world, currently is endured without a known cure. Some find the condition tolerable, while others are tortured on a daily basis from the incessant phantom noises. For those who seek treatment, oftentimes, they have a comorbid condition (e.g., depression, anxiety, insomnia), which is treated pharmaceutically. These products aim to reduce the comorbities associated with tinnitus thereby minimizing the overall burden present. Because of the phantom nature of tinnitus, it is often compared to neurologic pain. Since pain can be managed with pharmaceutical options, it is reasonable to assume that similar agents might work to alleviate tinnitus. The effects of antidepressants, benzodiazepines, anticonvulsants, and glutamate antagonists are reviewed in this paper. Table 1 summarizes the pharmaceutical products discussed. Due to the variety of comorbid factors and potential causes of tinnitus, there may not be one pharmaceutical treatment that will combat every type of tinnitus. Nevertheless, a product that finally addresses the true cause of tinnitus, and not just its comorbidities, will benefit millions of people worldwide.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.