ArticleAnatolian journal of cardiology2016
The association of paraoxonase 1 gene L55M polymorphism with the extent and severity of coronary artery disease in the Turkish population and its dependence on gender.
Article in Anatolian journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Associations of the PON1 rs854560 polymorphism with plasma lipid levels: a meta-analysis.Lipids in health and disease · 2018Pooled it
- Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients.Molecular biology reports · 2020Article
- Association of PON1-L55M Genetic Variation and Breast Cancer Risk: A Case-Control Trial.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Relationship between Paraoxonase-1 and Arylesterase Enzyme Activities and SYNTAX I and II Scores in Patients with ST-Elevation Myocardial Infarction.The journal of Tehran Heart Center · 2019Article
- The association between pre-miR-27a rs895819 polymorphism and myocardial infarction risk in a Chinese Han population.Lipids in health and disease · 2018Article
- Article
- Association between paraoxonase-1 gene Q192R and L55M polymorphisms in systemic lupus erythematosus (SLE) and anti-phospholipid syndrome (APS) in a population from Cairo of Egypt.Clinical rheumatology · 2017Article
- Relationship between rs854560Disease markers · 2017Article
- Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship.PloS one · 2016Article
- Q192R polymorphism in the PON1 gene and familial hypercholesterolemia in a Saudi population.Annals of Saudi medicineArticle
- Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCoronary artery disease (CAD) is a common, complex, and progressive disorder characterized by the accumulation of lipids and fibrous elements in the arteries. It is one of the leading causes of death in industrialized nations. Oxidative modification of low-density lipoprotein (LDL) in the arterial wall plays an important role in the initiation and progression of atherosclerosis. Paraoxonase1 (PON1) is involved in lipid metabolism and is believed to protect LDL oxidation. In our study, we aimed to clarify the relationship between PON1 gene L55M polymorphism and the extent and severity of CAD.
methodsIn total, 114 patients (54 males, mean age: 56.7 ± 12.0 years; 60 females, mean age: 55.7 ± 13.2 years) with stable angina or angina equivalent symptoms were enrolled in this prospective study. Cardiological evaluation was performed with electrocardiogram and transthoracic echocardiogram. The presence of hypertension, dyslipidemia, diabetes, and smoking status were ascertained. The patients were grouped according to their Gensini scores and gender. Genetic analysis of the PON1 gene L55M polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism.
resultsWe determined that the LL genotype was more prevalent in patients with Gensini score higher than or equal to 20 (p=0.026) and that this correlated with severe atherosclerotic coronary artery lesions in both gender groups, reaching a statistical significance in the female subjects (p=0.038).
conclusionIt was thought that the PON1 gene L55M polymorphism plays a significant role in CAD progression, especially in females.
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