ArticleBMC musculoskeletal disorders2015
Musculoskeletal pain is associated with restless legs syndrome in young adults.
Article in BMC musculoskeletal disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Investigating the Effect of Temperature Therapy on the Severity of Restless Legs Syndrome: Systematic Review and Meta-Analysis.Clinical medicine & research · 2023Pooled it
- Effect of Near-Infrared Light Therapy Based on Acupoints on the Severity of Restless Legs Syndrome in Patients Undergoing Hemodialysis: A Single-Blind, Randomized Controlled Trial.Clinical medicine & research · 2018Trial
- A Review of Movement and Functional Impairments in Fibromyalgia: Implications for Targeted Treatment.Journal of pain research · 2025Review
- Prevalence of fibromyalgia among university students and its impact on their health-related quality of life: a survey-based study from Egypt.BMC public health · 2023Article
- Oxidative stress involves phenotype modulation of morbid soreness symptoms in fibromyalgia.RMD open · 2023Article
- Back Pain without Disease or Substantial Injury in Children and Adolescents: A Twin Family Study Investigating Genetic Influence and Associations.Children (Basel, Switzerland) · 2023Article
- Restless legs syndrome in patients with chronic low back pain.British journal of pain · 2023Article
- Pramipexole treatment attenuates mechanical hypersensitivity in male rats experiencing chronic inflammatory pain.Neuropharmacology · 2022Article
- Influence of increased pain sensitivity on patient-reported outcomes following total knee arthroplasty.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Mechanisms underlying acupuncture therapy in chronic kidney disease: A narrative overview of preclinical studies and clinical trials.Frontiers in nephrology · 2022Review
- The effect of long-term poor sleep quality on risk of back-related disability and the modifying role of physical activity.Scientific reports · 2021Article
- The relationship between chronotypes and musculoskeletal problems in male automobile manufacturing workers.Annals of occupational and environmental medicine · 2021Article
- Number of Chronic Nighttime Insomnia Symptoms and Risk of Chronic Widespread Pain and Pain-Related Disability: The HUNT Study.Nature and science of sleep · 2020Article
- Chronic Widespread Pain and Fibromyalgia Syndrome: Life-Course Risk Markers in Young People.Pain research & management · 2019Review
- Effectiveness of fixed-site high-frequency transcutaneous electrical nerve stimulation in chronic pain: a large-scale, observational study.Journal of pain research · 2018Article
- Causal Mediation in the Development of Painful Temporomandibular Disorder.The journal of pain · 2017Article
- Sleep and restless legs syndrome in female adolescents with idiopathic musculoskeletal pain.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years, there is considerable evidence of a relationship between the sensorimotor disorder restless legs syndrome (RLS) and pain disorders, including migraine and fibromyalgia. An association between multi-site pain and RLS has been reported in adult women. In the current study, we explored the association between musculoskeletal (MSK) pain and RLS in a large cohort of young adults.
methodsTwenty two year olds (n = 1072), followed since birth of part of the Western Australian Pregnancy Cohort (Raine) Study, provided data on MSK pain (duration, severity, frequency, number of pain sites). RLS was considered present when 4 diagnostic criteria recommended by the International Restless Legs Syndrome Study Group were met (urge to move, dysaesthesia, relief by movement, worsening symptoms during the evening/night) and participants had these symptoms at least 5 times per month. Associations between MSK pain and RLS were analyzed by multivariable logistic regression with bias-corrected bootstrapped confidence intervals, with final models adjusted for sex, psychological distress and sleep quality.
resultsThe prevalence of RLS was 3.0 % and MSK pain was reported by 37.4 % of the participants. In multivariable logistic regression models, strong associations were found between RLS-diagnosis and long duration (three months or more) of MSK pain (odds ratio 3.6, 95 % confidence interval 1.4-9.2) and reporting three or more pain sites (4.9, 1.6-14.6).
conclusionsDifferent dimensions of MSK pain were associated with RLS in young adults, suggestive of shared pathophysiological mechanisms. Overlap between these conditions requires more clinical and research attention.
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