ReviewJournal of stroke2016
Silent New Brain Lesions: Innocent Bystander or Guilty Party?
Review in Journal of stroke, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03433235 (Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation: a Randomized, Multi-center, Parallel-group Trial (PILOT)
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- A web-based dynamic nomogram for individualized risk prediction of magnetic resonance imaging-defined cerebral small-vessel disease: Model development and internal validation.The Journal of international medical research · 2026Article
- Automated detection of new cerebral infarctions and prognostic implications using deep learning on serial MRI.NPJ digital medicine · 2026Article
- DWI-based deep learning radiomics nomogram for predicting the impaired quality of life in patients with unruptured intracranial aneurysm developing new iatrogenic cerebral infarcts following stent placement: a multicenter cohort study.Neurosurgical review · 2025Article
- Incident Infarcts in Patients With Stroke and Cerebral Small Vessel Disease: Frequency and Relation to Clinical Outcomes.Neurology · 2024Article
- Detection of microemboli in patients with acute ischaemic stroke and atrial fibrillation suggests poor functional outcome.European stroke journal · 2024Article
- Outcomes of non-vitamin K oral anticoagulants for secondary prevention in ischemic stroke with atrial fibrillation.Scientific reports · 2024Article
- Blood urea nitrogen to albumin ratio is associated with cerebral small vessel diseases.Scientific reports · 2024Article
- Monocyte to high-density lipoprotein cholesterol ratio is associated with cerebral small vessel diseases.BMC neurology · 2024Article
- Association of Body Shape Index with Cerebral Small Vessel Disease.Obesity facts · 2023Article
- The Atherogenic Index of Plasma is Associated With Cerebral Small Vessel Disease: A Cross-Sectional Study.Journal of lipid and atherosclerosis · 2022Article
- Patient tilt improves efficacy of COJournal of cardiothoracic surgery · 2022Article
- Ischemia in intracerebral hemorrhage: A comparative study of small-vessel and large-vessel diseases.Annals of clinical and translational neurology · 2022Observational
- Effects of cerebral small vessel disease on the outcomes in cryptogenic stroke with active cancer.Scientific reports · 2021Article
- Predictive value of perfusion weighted imaging for early new lesions after stroke patients receive endovascular treatment.Quantitative imaging in medicine and surgery · 2021Article
- Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3.European stroke journal · 2021Article
- High triglyceride-glucose index is associated with subclinical cerebral small vessel disease in a healthy population: a cross-sectional study.Cardiovascular diabetology · 2020Observational
- Distinct association between cerebral arterial pulsatility and subtypes of cerebral small vessel disease.PloS one · 2020Article
- Early Recurrent Ischemic Lesions in Patients With Cryptogenic Stroke and Patent Foramen Ovale: An Observational Study.Frontiers in neurology · 2018Article
- Deep into the Brain: Artificial Intelligence in Stroke Imaging.Journal of stroke · 2017Review
- Cerebral microbleeds in a neonatal rat model.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the advances in magnetic resonance imaging, previously unrecognized small brain lesions, which are mostly asymptomatic, have been increasingly detected. Diffusion-weighted imaging can identify small ischemic strokes, while gradient echo T2* imaging and susceptibility-weighted imaging can reveal tiny hemorrhagic strokes (microbleeds). In this article, we review silent brain lesions appearing soon after acute stroke events, including silent new ischemic lesions and microbleeds appearing 1) after acute ischemic stroke and 2) after acute intracerebral hemorrhage. Moreover, we briefly discuss the clinical implications of these silent new brain lesions.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.