ReviewJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2016
Treatment of inappropriate sinus tachycardia with ivabradine.
Review in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden.Nature reviews. Cardiology · 2024Review
- Autonomic Manifestations of Long-COVID Syndrome.Current neurology and neuroscience reports · 2023Review
- Onset of Postural Orthostatic Tachycardia Syndrome (POTS) Following COVID-19 Infection: A Pediatric Case Report.Clinical pediatrics · 2023Article
- Ivabradine in Cardiovascular Disease Management Revisited: a Review.Cardiovascular drugs and therapy · 2021Review
- Ivabradine use in pregnant women-treatment indications and pregnancy outcome: an evaluation of the German Embryotox database.European journal of clinical pharmacology · 2021Observational
- Baseline intrinsic heart rate and response to ivabradine treatment in patients with inappropriate sinus tachycardia.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2020Article
- Late Outcomes of Surgical Ablation for Inappropriate Sinus Tachycardia.The Annals of thoracic surgery · 2019Article
- Canine and human sinoatrial node: differences and similarities in the structure, function, molecular profiles, and arrhythmia.Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology · 2019Review
- Inappropriate Sinus Tachycardia: Current Challenges and Future Directions.The Journal of innovations in cardiac rhythm management · 2018Article
- Challenges in Treatment of Inappropriate Sinus Tachycardia.Current cardiology reviews · 2018Review
- Genetic background dominates the susceptibility to ventricular arrhythmias in a murine model of β-adrenergic stimulation.Scientific reports · 2018Article
- Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If "funny" current.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInappropriate sinus tachycardia (IST) often causes palpitations, dyspnea, and exercise intolerance, that are generally treated with beta blockers and non-dihydropyridine calcium-channel antagonists. Ivabradine, a selective inhibitor of cardiac pacemaker If current, has recently emerged as an effective and safe alternative to conventional drugs for IST.
methodsWe performed a systematic overview of clinical studies on the therapeutic yield of ivabradine in patients with inappropriate sinus tachycardia, published in MEDLINE database from January 2000 to March 2015.
resultsOverall, five case reports were found, all showing efficacy of ivabradine in subjects affected by IST. Eight non-randomized clinical studies demonstrated short- and medium-term safety and efficacy of ivabradine administration in IST, also in adjunction to or in comparison with metoprolol. One double-blind randomized crossover study also showed that ivabradine is superior to placebo for heart rate (HR) reduction and symptoms control in patients affected by IST.
conclusionsIvabradine is effective and safe in short- and medium-term treatment of IST. However, long-term follow-up studies and randomized studies comparing ivabradine with beta blockers are still lacking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.