Evidence map›Paper›PMID 26467091›Full record

ArticleBMC medical informatics and decision making2015

Predicting asthma control deterioration in children.

Gang Luo, Bryan L Stone, Bernhard Fassl, Christopher G Maloney, Per H Gesteland, Sashidhar R Yerram, Flory L Nkoy

Open access · goldAbstract read
In one paragraph

Article in BMC medical informatics and decision making, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Review
  6. Leveraging artificial intelligence for the management of preschool wheeze: A narrative review.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gang LuoDepartment of Biomedical Informatics, University of Utah, Suite 140, 421 Wakara Way, Salt Lake City, UT, 84108, USA. gang.luo@utah.edu.
Bryan L StoneDepartment of Pediatrics, University of Utah, 100 N Mario Capecchi Drive, Salt Lake City, UT, 84113, USA.
Bernhard FasslDepartment of Pediatrics, University of Utah, 100 N Mario Capecchi Drive, Salt Lake City, UT, 84113, USA.
Christopher G MaloneyDepartment of Pediatrics, University of Utah, 100 N Mario Capecchi Drive, Salt Lake City, UT, 84113, USA.
Per H GestelandDepartment of Pediatrics, University of Utah, 100 N Mario Capecchi Drive, Salt Lake City, UT, 84113, USA.
Sashidhar R YerramDepartment of Biomedical Informatics, University of Utah, Suite 140, 421 Wakara Way, Salt Lake City, UT, 84108, USA.
Flory L NkoyDepartment of Pediatrics, University of Utah, 100 N Mario Capecchi Drive, Salt Lake City, UT, 84113, USA.
University of Utah · US

Funding

University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
Mentored Scholars Program for Translational Comparative Effectiveness ResearchKM1CA156723 · NCI · UNIVERSITY OF UTAH · PI BYINGTON, CARRIE L. · 2010 to 2010
$2.5M
Improving Post-Hospital Transitions and Ambulatory Care for Children with AsthmaR18HS018678 · AHRQ · UNIVERSITY OF UTAH · PI NKOY, FLORY L · 2011 to 2013
$1.1M
University of Utah Center for clinical and Translational ScienceKL2TR001065 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$1.1M
Organizational Factors Associated with Improved Inpatient Pediatric Asthma CareR18HS018166 · AHRQ · UNIVERSITY OF UTAH · PI NKOY, FLORY L · 2010 to 2012
$884k
AHRQ HHS 1R18HS018166-01A1AHRQ HHS 1R18HS018678-01A1AHRQ HHS R18 HS018166AHRQ HHS R18 HS018678NCATS NIH HHS KL2 TR001065NCATS NIH HHS UL1 TR001067NCI NIH HHS KM1 CA156723NCI NIH HHS KM1CA156723
6 · The paper itself

Abstract

backgroundPediatric asthma affects 7.1 million American children incurring an annual total direct healthcare cost around 9.3 billion dollars. Asthma control in children is suboptimal, leading to frequent asthma exacerbations, excess costs, and decreased quality of life. Successful prediction of risk for asthma control deterioration at the individual patient level would enhance self-management and enable early interventions to reduce asthma exacerbations. We developed and tested the first set of models for predicting a child's asthma control deterioration one week prior to occurrence.

methodsWe previously reported validation of the Asthma Symptom Tracker, a weekly asthma self-monitoring tool. Over a period of two years, we used this tool to collect a total of 2912 weekly assessments of asthma control on 210 children. We combined the asthma control data set with patient attributes and environmental variables to develop machine learning models to predict a child's asthma control deterioration one week ahead.

resultsOur best model achieved an accuracy of 71.8 %, a sensitivity of 73.8 %, a specificity of 71.4 %, and an area under the receiver operating characteristic curve of 0.757. We also identified potential improvements to our models to stimulate future research on this topic.

conclusionsOur best model successfully predicted a child's asthma control level one week ahead. With adequate accuracy, the model could be integrated into electronic asthma self-monitoring systems to provide real-time decision support and personalized early warnings of potential asthma control deteriorations.

Indexed as

Models, StatisticalAdolescentAsthmaChildChild, PreschoolFemaleHumansMachine LearningMalePrognosisSensitivity and Specificity

Identifiers

PMID26467091
PMCPMC4607145
OpenAlexW2105979504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.