ArticleInternational journal of immunopathology and pharmacology2015
Tinospora cordifolia inhibits autoimmune arthritis by regulating key immune mediators of inflammation and bone damage.
Article in International journal of immunopathology and pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Exploring herbal synergies in the management of rheumatoid arthritis: a multifaceted approach to inflammation and joint health.Inflammopharmacology · 2025Review
- Targeting rheumatoid arthritis risk factors with phytochemicals: an anti-inflammatory perspective.Inflammopharmacology · 2025Review
- Pharmacological and immunomodulatory modes of action of medically important phytochemicals against arthritis: A molecular insight.Molecular biology reports · 2024Review
- Review
- A Review of the Occurrence of Rheumatoid Arthritis and Potential Treatments through Medicinal Plants from an Indian Perspective.Current rheumatology reviews · 2024Review
- Therapeutic Application, Phytoactives and Pharmacology of Tinospora cordifolia: An Evocative Review.Chinese journal of integrative medicine · 2023Review
- Fighting cytokine storm and immunomodulatory deficiency: By using natural products therapy up to now.Frontiers in pharmacology · 2023Review
- Integrated omics analysis revealed theJournal of diabetes and metabolic disorders · 2022Article
- Deciphering the mechanism ofFrontiers in pharmacology · 2022Article
- Ayurveda Rasayana as antivirals and immunomodulators: potential applications in COVID-19.Environmental science and pollution research international · 2021Review
- Intervention of Ayurvedic drugJournal of diabetes and metabolic disorders · 2020Article
- Using Guduchi (Tinospora cordifolia) as an eco-friendly feed supplement in human and poultry nutrition.Poultry science · 2020Review
- Modulation of Inflammatory Response to Implanted Biomaterials Using Natural Compounds.Current pharmaceutical design · 2017Review
- Humoral immune and adjuvant responses of mucosally-administered Tinospora cordifolia immunomodulatory protein in BALB/c mice.Journal of Ayurveda and integrative medicineArticle
- Tinospora cordifolia extract prevents cadmium-induced oxidative stress and hepatotoxicity in experimental rats.Journal of Ayurveda and integrative medicineArticle
- Modulation of neutrophil (dys)function by Ayurvedic herbs and its potential influence on SARS-CoV-2 infection.Journal of Ayurveda and integrative medicineReview
- Evaluation of Antithrombotic Activities ofPharmacognosy researchArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints leading to tissue damage. Despite the availability of potent drugs including the biologics, many patients fail to respond to them, whereas others suffer adverse effects following long-term use of these drugs. Accordingly, the use of natural herbal products by RA patients has been increasing over the years. However, limited information about the mechanism of action of these natural products is a major shortcoming that prevents the widespread acceptance of herbal therapy by professionals and patients alike. In this study, we demonstrated the anti-arthritic activity of Tinospora cordifolia extract (TCE) using the rat adjuvant-induced arthritis model of human RA and elaborated the immune mechanisms underlying this effect. TCE treatment suppressed arthritic inflammation and bone and cartilage damage. The anti-inflammatory effect of TCE was mediated via reduction of the pro-inflammatory cytokines such as: IL-1β, TNF-α, IL-6, and IL-17; the frequency of IL-17-producing T cells; and the production of chemokines such as RANTES. Furthermore, TCE treatment limited bone damage by shifting the balance of mediators of bone remodeling (e.g., receptor activator of nuclear factor-kB ligand [RANKL] and MMP-9) in favor of anti-osteoclastic activity. Our results suggest that TCE and its bioactive components should be evaluated for their utility as therapeutic adjuncts to conventional drugs against RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.